摘要
目的:研究血必净注射液治疗脓毒性休克患者的临床疗效。方法:将2006年4月—2007年3月收入江苏省苏北人民医院危重病医学科的48例脓毒性休克患者随机分为对照组和血必净组,每组24例。对照组按照脓毒性休克治疗指南进行治疗;血必净组在对照组治疗基础上加用血必净注射液50 ml静脉滴注,每日2次,连续用7 d。记录治疗前后患者的生命体征、白细胞计数(WBC)和Marshall评分,并抽取外周血,采用酶联免疫吸附法(ELISA)检测血清白细胞介素-6(IL-6)和IL-10水平,并记录患者28 d的病死率。结果:疗程结束时血必净组体温〔(37.2±0.6)℃比(37.9±0.6)℃〕、WBC〔(9.6±2.2)×109/L比(11.2±1.5)×109/L〕、Marshall评分〔(2.1±1.9)分比(2.8±1.8)分〕、IL-6〔(0.37±0.34)ng/L比(2.33±2.06)ng/L〕、IL-10〔(0.82±0.66)ng/L比(2.98±1.99)ng/L〕及28 d的病死率(4.2%比25.0%)明显低于对照组(P<0.05或P<0.01)。结论:血必净注射液可以改善脓毒性休克患者预后,其作用机制可能为通过调控炎症反应实现。
Objective： To study the clinical therapeutic effect with Xuebijing injection（血必净注射液） on treatment of patients with septic shock.Methods： Forty-eight patients in the department of critical care medicine of Subei People＇s hospital of Jiangsu province admitted from April 2006 to March 2007 were randomly divided into control group and Xuebijing group（each n=24）. The patients in the control group were treated following the therapy guideline of septic shock.In addition to the treatment in the control group,Xuebijing injection was used,50 ml intravenous drip twice a day for consecutive 7 days in Xuebijing group.Vital signs,white blood cell count（WBC） and Marshall score were recorded before and 7 days after treatment;peripheral blood was extracted,and enzyme linked immunosorbent assay（ELISA） was used to detected the plasma interleukin-6（IL-6） and IL-10.The mortality in twenty eight days were recorded.Results： After the therapeutic course,the comparisons between Xuebijng group and control group were as follows： temperature（（37.2±0.6）℃ vs.（37.9±0.6）℃）,WBC（（9.6±2.2）×109/L vs.（11.2±1.5）×109/L）,Marshall score（（2.1±1.9） scores vs.（2.8±1.8）scores）,IL-6（（0.37±0.34） ng/L vs.（2.33±2.06） ng/L）,IL-10（（0.82±0.66） ng/L vs.（2.98±1.99） ng/L） and mortality in 28 days（4.2% vs.25.0%） ,showing that all the above items in the Xuebijing group were lower than those in the control group（P〈0.05 or P〈0.01）.Conclusion： Xuebijing injection improves the prognosis of patients with septic shock,the mechanism may be related to the regulation of inflammatory reaction.
出处
《中国中西医结合急救杂志》
CAS
2007年第6期364-366,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
关键词
血必净注射液
脓毒性休克
炎症介质
Xuebijing injection
septic shock
mediators of inflammation
