基因治疗与扩张型心肌病
摘要
扩张型心肌病(Dilated cardlomyopathv,DCM)是一类既有遗传又有非遗传原因造成的复合型心肌病,以左心室或双心室扩大和收缩功能障碍等为特征。DCM的病因和发病机制,包括遗传基因因素、病毒持续感染、细胞和体液免疫反应等。近年来随着心脏病治疗技术的发展,DCM的治疗效果取得了较大的进步。治疗手段包括药物治疗、心脏起搏再同步化治疗、左室减容成形术、左心室机械辅助循环及心脏移植治疗等。
出处
《中国心血管病研究》
CAS
2007年第12期934-937,共4页
Chinese Journal of Cardiovascular Research
参考文献20
-
1[1]Tsubata S,Bowles KR,Vatta M,et al.Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy.J Clin Invest,2000,106:655-662. 被引量:1
-
2[2]Sakamoto A,Ono K,Abe M.Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene,deltasarcoglycan,in hamster:an animal model of disrupted dystrophin-associated glycoprotein complex.Proc Natl Acad Sci,1997,94:13873-13878. 被引量:1
-
3[3]Hack AA,Groh Me,Mcnally EM.Sarcoglycans in muscular dystrophy.Microsc Res Tech,2000,48:167-180. 被引量:1
-
4[4]Ryoke T,Gu Y,Mao L,et al.Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition.Circulation,1999,100:1734-1743. 被引量:1
-
5[5]Kawada T,Nakazawa M,Nakauchi S,et al.Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy:amelioration of morphological findings,sarcolemmal permeability,cardiac performances,and the prognosis of TO-2hamsters.Proc Natl Acad Sci USA,2002,99:901-906. 被引量:1
-
6[6]Svensson EC,Marshall DJ,Woodard K.Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors.Circulation,1999,99:201-205. 被引量:1
-
7[7]Nakagnmi H,Murishita R,Yamamutuk K,et al.Mitogenic and antiapoptotlc actions of hepatocyte growth factor through ERK,STAT3,and AKT in endothelial cells.Hypertension,2001,37:581-586. 被引量:1
-
8[8]Nakamura Y,Murishita R,Higaki J,et al.Hepatocyle growth factor is a novel member of the endothelium-specific growth factors:additive stmulatory effect of hepatocyte growth factor with basic fi broblast growth factor but not with vascular endothelial growth factor.J Hypertens,1996,14:1067-1072. 被引量:1
-
9[9]Matsumoto K,Nakamura T.Emerging multipotent sspects of hepatocyte growth factor.J Biochem Tokyo,1996,119:591-600. 被引量:1
-
10[10]Heller R,Jaroszeski M,Atkin A,et al.In vivo electroinjection and expression in rat liver.FEBS Lett,1996,389:225-228. 被引量:1
-
1赵爱荣.药物联合CRT-P治疗2例扩张型心肌病患者的体会[J].中国医药指南,2015,13(13):219-220. 被引量:1
-
2唐汉英.肾综合征出血热病毒持续感染细胞的建立[J].浙江预防医学,1996,8(2):52-53.
-
3王新国,唐海峰,乔敏,任鸿亮.苦参素治疗慢性乙型肝炎42例疗效观察[J].世界今日医学杂志,2001,2(1):76-77.
-
4徐洪,臧旺福.终末期心力衰竭治疗进展及新方法[J].中国心血管病研究,2009,7(7):552-555. 被引量:4
-
5朱东辉,申志英.对36例扩张型心肌病患者饮食中药疗法的体会[J].中国疗养医学,2007,16(9):544-546.
-
6余建国,李运安,张骅.血必净注射液联合阿德福韦酯治疗慢性乙型肝炎临床研究[J].肝脏,2013,18(5):351-352.
-
7尚建中,马龙飞,姚欣.中西医结合治疗慢性乙型肝炎的临床观察[J].中国中西医结合杂志,2002,22(9):703-704. 被引量:1
-
8张红,张如坤.拉米夫定联合苦参素治疗慢性乙型肝炎近期疗效观察[J].江西医药,2002,37(1):28-29. 被引量:2
-
9范晓晨,都鹏飞.病毒性心肌炎心肌内病毒持续感染的研究进展[J].国外医学(儿科学分册),1999,26(6):319-322.
-
10郭庆生.苦参素注射液联合胸腺肽治疗慢性乙型肝炎64例疗效分析[J].基层中药杂志,2002,16(4):61-62.