摘要
通过二乙三胺五乙酸的双N-羟基琥珀酰亚胺活性酯与含氨基的乳糖或D-半乳糖衍生物反应，合成了8种含有D-半乳糖基的二乙三胺五乙酸非离子型配体，并进一步合成了其钆（Ⅲ）配合物．配体及配合物的结构经IR、1HNMR与元素分析表征，对配合物的体外弛豫性能和小鼠急性毒性作了初步研究．家兔的磁共振成像实验表明这类造影剂具有肝靶向的特性．
New lactose-or D-galactose-containing diethylenetriaminepentaacetic acidbisamide ligands and their gadolinium complexes were synthesized by the reaction of bis(N-hydroxysuccinimide ester)of diethylenetriaminepentaacetic acid with amino-containing lac-tose or D-galactose derivatives. Chemical structures of ligands and Gd complexes were char-acterized. In vitro spin-lattice relaxivity and acute toxicity in mice of the complexes havebeen preliminarily investigated. Magnetic Resonance lmaging for rabbit shows that the con-trast agent bearing galactose could be targeted to the liver.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1997年第7期1072-1079,共8页
Chemical Journal of Chinese Universities
基金
国家教育委员会博士点基金
关键词
弛豫性能
肝靶向性
磁共振成像
MRI
造影剂
DTPA
MRI contrast agents
D-Galactopyranosyl group
Relaxivity
Acute toxicity
Liver-targeting
