摘要
目的:探讨食管原发性未分化小细胞癌临床病理特点。方法:对食管未分化小细胞癌进行形态学、免疫组化及电镜观察。结果:食管未分化小细胞癌是发生于食管的神经内分泌肿瘤,光镜下主要由小的间变性细胞构成,胞浆稀少,核卵圆形,染色质丰富,常较一致,核仁不明显,核分裂多见。免疫组化瘤细胞CK、NSE、Syn、CgA常为阳性。电镜检查还可查见神经内分泌颗粒。结论:食管未分化小细胞癌是一种罕见的恶性肿瘤,预后非常差。
Objective： To investigate the clinicopathologic features of undifferentiated small cell carcinoma of esophagus. Methods： The lesions were investigated by morphologic, immunohistochemical and electron - microscopic approaches. Results.. Undifferentiated small cell carcinoma of esophagus belongs to a neuroendocrine carcinoma of esophagus. Microscopically, the tumor was composed of undifferentiated cells with fewer cytoplasm, oval nucleus, lots of chromatin , unclear nucleolus and easily seen karyokinesis. In immunohistochemistry test, the tumor cells were positive for CK, NSE, Syn and CgA. Ultrastructurally, the neurosecretory granules were observed. Conclusion： Undifferentiated small cell carcinoma of esophagus is a rare malignant tumor. Its diagnosis and differential diagnosis mostly relied on histopathology, immunohistochemistry and electron microscopy. Its prognosis is very poor.
出处
《现代肿瘤医学》
CAS
2007年第12期1772-1774,共3页
Journal of Modern Oncology
关键词
未分化小细胞癌
食管
免疫组化
电镜
undifferentiated small cell carcinoma
esophagus
immunohistoehemistry
electron - microscopy
