摘要
目的探讨2型糖尿病患者合并高尿酸血症时对心血管系统的影响。方法142例2型糖尿病患者分为高尿酸组和对照组,高尿酸组29例(占20.42%),对照组113例(占79.58%)。对其血脂代谢指标、血清同型半胱氨酸水平和超声心动图结果等临床资料进行回顾性分析。结果①血脂指标比较,高尿酸组甘油三酯(triglyceride,TG)水平明显高于对照组[(2.36±1.54)mmol/Lvs(1.62±1.04)mmol/L;p<0.05];高密度脂蛋白(high density lipoprotein,HDL)低于对照组(P=0.07)。②同型半胱氨酸水平,高尿酸组明显高于对照组[(18.15±8.12)μmol/Lvs(14.02±4.34μmol/L;P<0.05)]。③高尿酸组左室后壁厚度大于对照组[(10.01±1.15)mmvs(9.40±0.72)mm,P<0.01],室间隔厚度也大于对照组[(11.36±1.59)mmvs(10.46±1.09)mm,P<0.01]。结论2型糖尿病合并高尿酸血症可加重血脂代谢异常,升高血清同型半胱氨酸水平,并可促使左室后壁、室间隔厚度增加。
[Objective] To investigate cardiovascular changes in patients with type 2 diabetes combined with hyperuricemia. [Methods] One hundred and forty-two patients with type 2 diabetes were divided into two groups： the hyperuricemia group（H-uri group） and the control group. Datum included blood lipids, serum homocysteine level and echocardiography results were investigated retrospectively. [Results]①Serum triglyceride （TG） level in the H-uri group was higher than the control group[（2.36＋l.54）mmol/L vs （1.62＋1.04）mmol/L; P 〈0.05];②Serum homocys-teine level in the H-uri group was higher than the control group[（18.15＋8.12）μmol/L vs （14.02±4.34μmol/L; P 〈 0.05）]. ③Left ventricular posterior wall thickness （LVPWT） in the H-uri group was thicker than the control group [（10.01±1.15）mm vs （9.40±0.72）mm, P 〈0.01], and interventricular septum thickness（IVST） was also thicker in the H-uri group than the control [（11.36±1.59）mm vs（10.46±1.09）mm, P 〈0.01]. [Conclusions] Type 2 diabetes accompanied with hyperuricemia may lead to hypertriglyceridemia and rising serum homocysteine level. Left ventricular remodeling is present in patients with type 2 diabetes accompanied with left ventricular diastolic function exacer-bation.
出处
《中国医学工程》
2007年第8期665-667,共3页
China Medical Engineering
