摘要
目的观察阿托伐他汀对2型糖尿病合并混合性血脂异常的改善作用。方法应用阿托伐他汀对39例2型糖尿病合并混合性血脂异常患者进行为期6个月的治疗,观察治疗前后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的变化及不良反应。结果治疗前后TG、TC、LDL-C较治疗前显著降低,降低程度分别为26.17%、54.97%、38.92%;HDL-C治疗后明显上升.上升幅度为14.81%,治疗前后比较,P<0.01。无明显不良反应发生。结论阿托伐他汀对2型糖尿病合并混合性血脂异常有明显改善作用,安全性较好。
Objective To observe the effect of atorvastatin on mixed dyslipidemia in type 2 diabetic patients. Methods 39 patients of type 2 diabetic with mixed dyslipidemia were taken with atorvastatin for 6 months,and the change of total cholesterel（ TC）, triglyceride（TG）, low-debsity-lipoprotein-cholesteral（ LDL-C）, high-debsity-lipoprotein-cholesteral（HDL-C） were observed. The incidence of side-effect was recorded. Results TC,TG, LDL-C were obviously reduced and their extent of reduction were 26.17 % , 54.97 % , 38.92 %. HDL-C was obviously increased and it＇s extent of increase was 14.81% （P 〈 0.01 ）. No serious side-effect were found. Conclusion Atorvastatin treatment may obviously improve the blood lipid levels on mixed dyslipidemia in type 2 diabetic patients. It was proved safe.
出处
《中国基层医药》
CAS
2007年第10期1645-1646,共2页
Chinese Journal of Primary Medicine and Pharmacy
