摘要
以7-氨基头孢烷酸(7-ACA)为原料,经水解、氨基保护、酯化制得(6R,7R)-3-羟甲基-8-氧-7-邻羟苯亚甲氨基-5-硫-1-氮杂二环[4.2.0]辛-2-烯-2-羧酸二苯甲酯,收率达84.6%,产品结构经IR1、HNMR表征。
Benzhydryl （6R, 7R）-3-hydroxymethyl-8-oxo-7-salicylideneamino-5-thia-1-azabicyclo[4. 2. 0]oct-2-ene-2- carboxylate was prepared by hydrolyzing 7-amino cephalosporanic acid（7-ACA）,protecting amino and following esterificaring. And the yield could reach 84.6 %. The target compound was characterized by IR and 1^HNMR.
出处
《化学与生物工程》
CAS
2007年第8期25-26,共2页
Chemistry & Bioengineering
关键词
头孢菌素
中间体
合成
cephalosporin
intermediate
synthesis
