摘要
目的探讨CD105和TGF-β1在非小细胞肺癌(NSCLC)中的表达及临床意义。方法运用免疫组织化学SP法检测CD105和TGF-β1在50例NSCLC和15例非肿瘤性肺组织中的表达,分析它们与NSCLC临床病理特征的关系。结果肿瘤组织中,CD105标记的微血管密度(MVD)明显高于非肿瘤性肺组织(P<0.01),NSCLC分化越低,CD105标记的MVD值越高,且Ⅲ、Ⅳ期MVD值显著高于Ⅰ、Ⅱ期(P<0.01),淋巴结转移组的MVD值显著高于无淋巴结转移组(P<0.01)。TGF-β1在NSCLC和非肿瘤组织中的阳性表达率分别为92%和42%,两者间的差异具有高度统计学意义(P<0.01)。TGF-β1表达强度与NSCLC的临床分期及淋巴结有无转移密切相关(P<0.01),同时与肿瘤中MVD值呈正相关关系(r=0.444,P<0.01)。结论CD105和TGF-β1在NSCLC生长、浸润和转移过程中发挥了一定的作用。
Objective To study the expression of clinical significances of CD105 and TGF-β1 in non-small cell lung cancer （NSCLC）. Methods The expression of CD105 and TGF-β1 were detected by SP immunohistoehemieal method in 50 patients with NSCLC and 15 patients with non tumorous lung tissue. Their relationship with elinieopathophysiologieal features was also analyzed. Results The mirero vessel density （MVD） marked by CD105 in NSCLC was markedly higher than that in the nontumorous lung tissue （P 〈 0.01）. The lower differentiation of NSCLC , the higher MVD was. The MVD in stage Ⅲ, IV was evidently higher than that in stage Ⅰ , Ⅱ （P〈0.01）, and the MVD was also higher in those with metastasis of lymph node than in those without metastasis（P〈 0.01）. The expression ratio of TGF-β1 in NSCLC and in non-tumorous lung tissue was 92% and 42% respectively, having significant difference （P 〈 0.01）. The TGF-β1 expression level correlated with clinical stages and metastasis of lymph nodes （ P 〈 0.01 ）, and had positive relationg with MVD in NSCLC（ r = 0. 444,P〈0.01）. Conelusion CD105 and TGF-β plays an important role in growth, invasion and metastasis in NSCLC.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2007年第4期555-557,共3页
Suzhou University Journal of Medical Science
基金
苏州大学第8批大学生课外学术科研基金资助项目(KY2005048A)
