摘要
首先以单分散性良好的PSA为模板,用还原铁盐方法生成PSA@Fe3O4核壳结构复合微球。再将生成的粒子加入到四氢呋喃(THF)溶剂中,使PSA模板溶解,得到Fe3O4空心微球。在一定条件下将葡聚糖吸附在磁性微球表面,得到吸附有高分子的磁性微球。采用X射线衍射(XRD)、透射电子显微镜(TEM)、傅立叶变换红外光谱(FT-IR)和热重分析(TGA)对制备的微球进行表征。粒子大小均匀,平均直径在50nm左右,Fe3O4层厚约为5nm。这种新颖的磁性高分子微球具有纳米级的尺寸和独特的空心结构。在生物医学领域特别是药物输运上可能具有广阔的应用前景。
An improved method of preparing magnetite-dextran microsphere is proposed. Several parameters were evaluated and the characteristics of the microspheres were investigated by XRD,TEM, FT-IRand TGA. The XRD results showed that the particles were indeed FeaO4. The transmission electron microscope images of the PSA@Fe3O4 exhibited that the nanoparticles with a diameter in the range of 30-100nm, the mean diameter is about 50nm.The resultant nanoparticles could be to have the capacity of encapsulation.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2007年第A05期1957-1960,共4页
Journal of Functional Materials
基金
国家自然科学基金资助项目(10672154):高等学校博士学科点专项科研基金(20050358010) 致谢:感谢中国科学院“百人计划”对本文的支持.
关键词
四氧化三铁
葡聚糖
磁性微球
magnetite-dextran
mierosphere
biocompatible