摘要
苯扎贝特是第二代苯氧乙酸类调脂药,主要用于IIb、III、IV型高血脂症的治疗。讲述苯扎贝特是以对羟基苯甲醛、盐酸盐、氯化物、氯仿为主要原料,通过酰化,缩合,等工序合成苯扎贝特,分析了合成过程中滴加速度、回流时间、反应pH值、反应温度等因素影响,并对苯扎贝特的熔点、水分、含量进行了检测。
Bezafibrate is the second generation phenyloxycarboxylic acid medicine , Bezafibrate is prepared from hydroxy benzaldehyde, hydrochloride, chloride and chloroform, Its four manufacturing processes are： acylation, condensation, pulping and refinemont. The requirements on reaction conditions are also very high. In this paper, the processes and the importance of reaction conditions were introduced. Through examination of the melting point, the moisture content, the content to the bezafibrate, the preparation craft was confirmed to be feasible.
出处
《辽宁化工》
CAS
2007年第11期733-735,738,共4页
Liaoning Chemical Industry
关键词
苯扎贝特
降脂药物
合成
Bezafibrate
Generation pHenyloxycarboxylic acid medicine
Synthesis
