摘要
目的:评估造影增强能量多普勒在评价肝癌血管生成中的价值。方法:应用声诺维造影剂增强能量多普勒研究32例肝癌,图像定量计算病灶内相对血流灌注率,与微血管密度(micro-vasculardensity,MVD)、血管内皮生长因子(vascular endothelial growth factor,VEGF)相对照,分析两者的相关性。结果:肝癌组织VEGF表达阳性组相对灌注率高于阴性组(P<0.05);造影增强能量多普勒血流等级及相对灌注率与MVD和VEGF相关(P<0.05)。结论:增强能量多普勒可有效评价肝癌的血管生成。
Objective To evaluate the role of contrast enhanced power Doppler in evaluating tumor angiogenetic activity. Methods Thirty-two patients with hepatocellular carcinoma were ana- lysed. Flow signals of hepatocellular carcinoma were observed by power Doppler imaging after the injection of contrast agent, and then the relative perfusion rate and blood flow were assessed. The microvessel density （MVD） and vascular endothelial growth factor （VEGF） were assessed by immuno-histochemical method. The relationship between the relative perfusion rate, blood flow, MVD, VEGF was studied. Results The relative perfusion rate in the tissues with positive expression of VEGF was significantly higher than that in the tissues with negative expression of VEGF in hepatocellular carcino- ma. There was correlation between the relative perfusion rate, blood flow grade and MVD （P 〈 0.05）. The expression of VEGF was positively related to the relative perfusion rate and blood flow grade （ P 〈 0.05 ）. Conclusion Contrast enhanced power Doppler is useful in evaluating the tumor angiogenetic activity.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2007年第5期840-844,共5页
Journal of Central South University ：Medical Science
基金
湖南省卫生科技计划课题基金(B2005073)
湘雅三医院博士化基金(2005-2007)~~
关键词
肝癌
能量多普勒
超声造影
血管生戍
hepatocellular carcinoma
power Doppler
contrast ultrasound
angiogenesis
