摘要
目的观察多西紫杉醇（TXT）联合氟尿嘧啶（5-Fu）持续静脉泵入及低剂量顺铂（DDP）组成的TCF方案治疗进展期胃癌的客观有效率（RR）、毒性反应及生存期。方法全组36例患者均经组织病理学证实。治疗前有可评价的客观指标。其中合并肺转移11例，肝转移12例，腹腔转移7例，腹壁转移5例，骨转移4例。TCF方案应用如下：TXT 60mg／m^2，ivdrip，d1；CF100～200mg／m^2，ivdrip，d1-5，于5-Fu之前用药；5-Fu 500mg，ivdrip，d1；5-Fu2～3g／m^2，civ，120h；DDP20—30mg／m^2，ivdrip，d3—5。每21d重复。结果全组36例均可评价疗效，CR3例，PR19例，sD6例，PD8例，总有效率为61．1％。中位生存期（MST）13个月。主要毒性反应是粒细胞下降、消化道反应和脱发。结论TCF方案治疗进展期胃癌客观疗效肯定，毒副反应轻，患者耐受性良好，可以广泛地应用于临床。
Objective To observe short-time efficacy and toxic reaction of TCF regimen in treatment of advanced gastric cancer（AGC） and survival time of patients treated. Methods Thirty-six cases were confirmed by pathology and diagnosed as AGC. Of them, 11 had metastasis in lung, 12 in liver,7 in abdominal cavity, 5 in abdominal wall, 4 in bone. The patients were given TXT 60 mg/m^2, iv gtt, d1 and CF 100- 200 mg/m^2 ,iv gtt,d1-5 ,before 5-Fu; 5-Fu 500mg iv gtt d1,5-Fu 2-3 g/m^2 ,civ 120 h;DDP 20-30 mg/m^2, iv gtt d3,4,5. The cycle was repeated every 21 days. Results The overall effective rate was 61.1%, including CR 3, PR 19 ,SD 6 and PD 8. Median survival time was 13 months. The main toxic reactions were granuloeytopenia, gastrointestinal reactions and alopecia. Conclusion TCF in treatment of advanced gastric cancer has good short-time efficacy, mild adverse reaction and good tolerance. It may be used widely in clinical work.
出处
《中国肿瘤临床与康复》
2007年第5期438-439,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
