摘要
【目的】探讨红葡萄酒对动脉粥样硬化的保护作用及其可能机制。【方法】选用50只雄性金黄地鼠,随机分为红葡萄酒组、红葡萄酒脱酒精样组、酒精组、高血脂组和对照组。在试验的4周内,除对照组饲喂基础饲料外,其余各组饲喂高脂饲料,处理组以15ml·kg-1体重进行灌胃。第4周末,取金黄地鼠血浆测定血脂指标,脂质过氧化产物丙二醛含量,同时对肝组织进行电镜观察。【结果】与高脂组比,红葡萄酒组、红葡萄酒脱酒精样组和酒精组金黄地鼠血浆总胆固醇和甘油三酯的水平极显著降低。各处理组血浆低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇水平极显著降低,但高密度脂蛋白胆固醇没有表现出显著性差异。载脂蛋白A1和载脂蛋白B各处理组与高脂组比较,没有显著性差异。各处理组肝脏指数显著降低。红葡萄酒组、红葡萄酒脱酒精样组和酒精组金黄地鼠血浆丙二醛值显著降低。【结论】红葡萄酒可以预防动脉粥样硬化的发生。
[Objective] To study the protective effect and mechanism of red wine and alcohol-free red wine on risk of atherosclerosis. [Method] This experiment was conducted with 50 male golden hamsters, which were divided into five groups, each of which contained 10 hamsters： red wine group, alcohol-free red wine group, alcohol group, hyperlipidemia group and control group During the 4 weeks, all hamsters were fed high cholesterol diets except control group. After completion of the trial, the plasma lipid levels and lipid peroxidation contents were determined in golden hamsters, and the morphological variation in liver cell was investigated with electron microscopy. [Result] Red wine, alcohol-free red wine and alcohol decreased significantly the concentrations of TC and TG in hamsters. Compared with the hyperlipidemia group, the levels of LDL-C were significantly decreased in other groups, but not the HDL-C. Consumption of red wine, alcohol-free red wine and alcohol, all had no significant effects on Apo ] and ApoB. Red wine, alcohol-free red wine and alcohol significantly decreased the contents of MDA in hamsters. [ Conclusion ]The experiment demonstrated that red wine can ameliorate the incidence of atherosclerosis by reducing serum TC, TG, LDL-C, and compounds of red wine have a co-operative effect.
出处
《中国农业科学》
CAS
CSCD
北大核心
2007年第11期2587-2592,共6页
Scientia Agricultura Sinica
基金
国家自然科学基金(30571281)资助
