摘要
探讨抗硫脂抗体与格林－巴利综合征（ＧＢＳ）的关系。方法采用固相酶联免疫吸附法对急性期ＧＢＳ患者血清和脑脊液（ＣＳＦ）中抗硫脂ＩｇＧ和ＩｇＭ抗体进行检测。结果ＧＢＳ患者血清和ＣＳＦ中抗硫脂ＩｇＧ及ＩｇＭ抗体的阳性率均明显高于正常对照组；血清中抗硫脂ＩｇＭ抗体滴度与标本收集时患者发病天数呈负相关（Ｐ＜０．０５），而血清中抗硫脂ＩｇＧ抗体滴度与临床分级（Ｐ＜０．０１）、ＣＳＦ中抗硫脂ＩｇＧ抗体滴度（Ｐ＜０．０１）呈正相关；血清中抗硫脂ＩｇＧ或ＩｇＭ阳性的ＧＢＳ患者，体检时有不同程度的感觉障碍患者为５６％，而血清中抗硫脂抗体阴性患者仅为１６％，两者之间差异有显著意义（Ｐ＜０．０５）。
Objective To investigate whether antibodies to sulphatide is associated with Guillain Barre syndrome (GBS). Methods Anti sulphatide IgM and IgG levels in the serum and CSF of patients with acute GBS were measured by solid phase enzyme linked immunosorbent assay. Results Compared to the control group,the levels of anti sulphatide antibody were more frequently elevated in serum and CSF of acute GBS patients than healthy subjects. The anti sulphatide IgM serum levels in pathients with acute GBS were inversely correlated with the time elapsed between sample collection and the onset of disease( P <0.05), whereas the serum anti sulphatide IgG levels were positively correlated with the loss of functional ability ( P <0.01) and those in the CSF serum antisoephatide levels ( P <0.01). 56% of the GBS patients who had high titres of anti sulphatide antibodies had some of degree of sensory impairment,However, only 16% of GBS patients whose serum anti sulphatide antibodies levels were not increased exhibited sensory impairment. Conclusions The presence of high titers of anti sulphatide antibodies in serum and CSF may play a role in the pathogenesis of GBS.
出处
《中华神经科杂志》
CAS
CSCD
1997年第3期135-137,共3页
Chinese Journal of Neurology
关键词
G-B综合征
硫脂
抗体
血清
脑脊液
Guilliain Barrè syndrome Sulphatide Antibody Enzyme linked immunosorbent assay
