摘要
目的：采用正交试验法对失笑滴丸的滴制工艺进行优选试验。方法：选择药液温度、滴头口径、药物与基质的配比、滴速等４因素，每个因素各取３个水平，按Ｌ９（３）４正交表安排实验，用３个指标评定工艺的优劣。结果：采用药液温度为９５℃、滴头口径内径为３．３ｍｍ、外径为５．２ｍｍ，药物与基质的配比为３．５∶６．５，以４０滴·ｍｉｎ－１的滴速滴入甲基硅油中的工艺条件最佳。结论：用正交试验法优选失笑滴丸的滴制工艺是可行的。
OBJECTIVE: To seek the optimum techniques making Shixiao pill by orhogonal test. METHODS: To arrange the test according to the L 9(3) 4 orthogonal table, we selected four factors as temperature of drug solution, diameters of dropper, ratio between drug and base and dropping rate, each of which took three levels, to assess the techniques good or bad in the three indexes. RESULTS: The optimum technique was that the temperature of drug solution was 95 ℃, the diameters of dropper were 3.3/5.2 mm(inside/outside), the ratio between drug and base was 3.5 ∶6.5, and the dropping rate into methylsilicone oil was 40 drops·min -1 . CONCLUSION: It's feasible to seek the optimum techniques making Shixiao pill by orthogonal test.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1997年第5期303-305,共3页
Chinese Pharmaceutical Journal
基金
广西壮族自治区卫生厅资助
关键词
失笑滴丸
正交试验
滴制工艺
中药
Shixiao drop pill, orthogonal test, techniques of making drop pill
