摘要
目的:探讨食管癌病人术后早期应用肠内营养支持的可行性、安全性及其临床效果。方法:将40例食管癌术后病人随机分为全肠外营养(TPN)组和早期肠内营养(EEN)组。所有病人在手术前1天、术后第1天和第8天各测定安全性指标、营养指标、免疫指标和急性炎性指标;观察术后并发症、住院时间等。结果:所有病人在研究期间无死亡,无严重并发症,无明显肝、肾功能改变;研究结束时,EEN组血清前清蛋白、外周血淋巴细胞总数、CD3、CD4、CD4/CD8比值明显高于TPN组;而IL-6明显低于TPN组;EEN组住院时间明显短于TPN组。结论:食管癌病人术后早期应用肠内营养支持,能改善病人的营养状况和免疫功能,减轻炎性反应,缩短住院时间。
Objective： To evaluate the feasibility,the safety and the effect of early postoperative enteral nutrition in patients with esophageal cancer.Methods： On the first postoperative day,40 patients were randomly divided into two groups.One group was given isocaloric total parenteral nutrition through central vein（TPN group） and the other group was fed with enteral nutrition through nasoenteric tubes or jejunostomy tubes which were inserted during the operation（EEN group）.All variables were measured before operation and on postoperative day 1 and 8.Blood was drawn at different time points to assess albumin,prealbumin and transferrin.Immune response was determined by immunoglobins,total lymphocytes,T-lymphocyte subsets and NK cells. Inflammatory response were determined by C-reactive protein,IL-6 and TNF-α.Morbidity,mortality and length of hospital stay were also evaluated. Results： Tolerance of enteral nutrition was excellent.Neither mortality nor serious morbidity occurred in all patients during the period of study.After the study,the levels of serum prealbumin,total lymphocytes,CD3,CD4 and CD4/CD8 ratio in the EEN group were significantly higher than the levels in the TPN group.The concentrations of IL-6 and the length of hospital stay in the EEN group were significantly lower than in the TPN group.Conclusion： Early postoperative enteral nutrition in patients with esophageal cancer is safe,and also has the benefit effects of enhancing the body status of nutrition and immune function,and reducing the inflammatory response and the length of hospital stay.
出处
《肠外与肠内营养》
CAS
2007年第5期282-285,共4页
Parenteral & Enteral Nutrition
关键词
食管癌
肠外营养
早期肠内营养
Esophageal cancer
Parenteral nutrition
Enteral nutrition
