摘要
目的采用胰岛素泵强化治疗2型糖尿病(T2DM)继发性磺酰脲类药物(SU)失效以评介其临床疗效。方法将45例继发性SU失效患者随机分为胰岛素泵持续皮下输注(CSII)组23例和多次皮下注射胰岛素(MDI)组22例,均连续2周,比较两组治疗前后的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、血糖达标时间、平均每日胰岛素(Ins)用量及低血糖反应。结果两组治疗后均能显著降低患者的FPG、2hPG、HbA1c(P均<0.01),但CSII组较MDI组降低更为明显(P<0.01),CSII组血糖达标时间短(P<0.01),平均每日Ins用量少(P<0.05),低血糖反应少(P<0.05)。结论胰岛素泵能更有效迅速地控制血糖,节省Ins用量,延缓胰岛B细胞功能衰竭,且低血糖反应少。
Objective To evaluate the effect of continuous subcutaneous insulin infusion （CSII） in the intensive treating of secondary sulfonylureas failure. Methods 45 patients with secondary sulfonylureas failure were divided into 2 groups randomly： Group 1 treated with CSII （ n = 23） and group 2 treated with multiple deliver insulin （MDI）（ n = 22）. The levels of blood glucose, HbA1 c, therapentic time to get target goal, average daily insulin dosage and frequency of hypolycemia were compared between two groups before and after 2 weeks of treatment. Results After treatment, compared with group 2 , the levels of FPG, 2hPG and HbA1 c in group 1 were lower（ P 〈 0.01 ）, the therapeatic time was shorter（ P 〈 0.01 ）, average daily insulin dosage and frequency of hypoglycemia were less（ P 〈 0.05）. Conclusions CSII improves the blood glucose control , saves insulin dosage obviously, delays the failure of islet B - cells function and has less frequency of hypoglycemia.
出处
《浙江临床医学》
2007年第11期1455-1456,共2页
Zhejiang Clinical Medical Journal
