摘要
目的探讨高血压病患者血浆脑钠肽(BNP)水平与左心室质量(LVM)比值(%PLM)的关系,并了解前者在高血压发生、发展过程中的变化。方法选取61例原发性高血压患者,依据LVM比值分为LVM不足组11例,LVM适宜组29例,LVM过高组21例,30例同期住院血压正常检查者为对照组。测定血浆脑钠肽含量,行超声心动图检查,计算左心室实际质量、LVM预计值。结果高血压组与对照组间BNP差异有统计学意义。对照组与LVM不足组、LVM适宜组、LVM过高组的BNP分别是(16.99±3.24)pg/L vs(11.5±5.37)pg/L,(35.81±4.64)pg/L,(60.84±10.49)pg/L,P<0.01,高血压各组间BNP差异也有统计学意义,以LVM过高组最高,LVM不足组与对照组间BNP差异无统计学意义(P>0.05);BNP与LVM比值呈正相关(r=0.499,P<0.05),与E/A比值呈负相关(r=-0.262,P<0.05);与LVEF、短轴缩短期(FS)、左心房大小、收缩压(SBP)、舒张压(DBP)无相关性。结论高血压病时血浆BNP升高,与LVM比值呈正相关,BNP与高血压左心室重构的发生、发展有关,并可以作为判断高血压病预后的一项无创生化指标。
Objective To investigate the relationship between plasma levels of brain natriuretic peptides（BNP） and the ratio of observed/predicted left ventricular mass（LVM）（% PLM）, find out the changes of BNP in essential hypertension（EH）. Methods Sixty-one patients of EH were selected and divided by % PLM into inadequate LVM group 11 cases, adequate LVM group 29 cases, inappropriately high LVM group 21 cases ; healthy control 30 cases, they were examined by echocardiography and plasma level of BNP, their LVM and LVM predicted value were calculated. Results Plasma level of BNP was significantly elevated in EH groups compared with that of control group and there was significant difference among EH three groups. Inappropriately high LVM was the highest （60.84±10.49） pg/L, there was no difference between inadequate LVM and control group, （16.99 ±3.24） pg/L vs（11.5 ：[： 5.37） pg/L, （35.81±4.64） pg/L（ P〉0.05）;there was a significant positive correlation between BNP and % PLM（ r=0. 449）, but negative with E/A ratio（ r=-0. 262）, and no relationship with LAD, SBP, DBP, LVEF, FS. Conclusion Plasma level of BNP raises in EH and has a positive relationship with %PLM,BNP has relationship with EH and can be used as a no trauma prognosis index of EH.
出处
《临床荟萃》
CAS
北大核心
2007年第21期1526-1528,共3页
Clinical Focus
关键词
高血压
利钠肽
脑
心室重构
hypertension
natriuretic peptides, brain
ventricular remodeling
