摘要
目的探讨盐酸万古霉素治疗高龄(>80岁)老年患者耐药葡萄球菌感染的临床疗效和不良反应。方法选择耐药葡萄球菌感染的高龄老年患者54例,应用万古霉素0.5g加入5%GS或0.9%NS100ml中静脉滴注,每8h1次,每次滴注1h以上,疗程1～2周。观察其临床疗效、细菌感染清除率、肝肾功能及肌酐清除率的变化。结果①万古霉素治疗后临床痊愈率为68.5%,有效率为88.9%,细菌清除率为64.8%;②治疗后血肌酐、肌酐清除率与治疗前比较差异无统计学意义(P>0.05);③治疗过程中5例(9.3%)出现不良反应。结论万古霉素对治疗高龄老年患者耐药葡萄球菌感染具有良好的疗效,只要合理使用,不会导致严重的肾功能损害。
Objective To explore the clinical efficiency and adverse reaction of vancomycin in treatment of oldest-old patient （ 〉 80 years） with drug-resistant staphylococcus infection. Methods 54 oldest old patients with drug-resistant staphylococcus infection were treated with vancomycin. Results The clinical cure rate was 68.5% ,the effective rate was 88.9% ,the clearance rate of bacteria was 64.8% after vancomycin therapy. The differences of blood creatinine and creatinine clearance rate before and after treatment was insignificant （ P 〉 0.05 ）. The incidence of adverse reaction was 9.3 %. Conclusions Vancomycin is effcet and safe treatment for drug-resistant staphylococcus infection in oldest-old patients. It could not cause serious renal function injury.
出处
《实用全科医学》
2007年第11期951-952,共2页
Applied Journal Of General Practice
关键词
盐酸万古霉素
高龄老年患者
耐药葡萄球菌感染
临床疗效
毒副作用
Vancomycin
Oldest-old patients
Drug-resistant staphylococcus infection
Clinical efficiency
Adverse reaction
