摘要
目的观察辛伐他汀对舒张功能不全心衰患者心功能和QT离散度的影响,并探讨其作用与氧自由基的关系。方法150例原发性高血压并舒张功能不全心衰患者(心功能Ⅱ-Ⅳ级)随机分为辛伐他汀组和对照组。两组患者均控制血压和抗心衰治疗,辛伐他汀组加服辛伐他汀每晚40mg,所有患者于用药前和治疗后8月进行心功能分级、血压检测、心功能超声评价、常规同步12导联心电图检查、血脂检查、试剂盒测定MDA、SOD和GSHPx。结果与用药前比较,辛伐他汀组和对照组患者均显示收缩压下降,NYHA心功能改善,IVS、PW、QTd、QTcd、MDA下降,E/A、SOD、GSHPx增加,血脂、舒张压、LVEDs、LVEDd和LVEF无改变;除收缩压外,其他有改善的指标其变化的程度在辛伐他汀组较对照组更为明显。结论在常规抗心衰基础治疗上加用辛伐他汀可进一步改善舒张功能不全心衰患者的心功能,降低QT离散度,这种保护作用可能与进一步降低舒张功能不全心衰患者的氧自由基有关。
Objective To study the effect of Simvastatin on cardiac function, QT dispersion and oxygen free radical of patients with diastolic heart failure. Methods 150 patients （NYHA Ⅱ-Ⅳ） were randomly divided into Simvastatin group and control group. Despite same blood control and treatment for heart failure in both groups, Simvastatin 40mg/d was added to patients in the Simvastatin group. NYHA cardiac function classification were judged and cardiac function was assessed by echocardiography before drug treatment and 8 months after that. Blood pressure, 12-leads ECG blood lipid MDA, SOD and GSH Px were also measured. Results Compared with those before drug treatment, NYHA cardiac function improved, SBP,IVS, PW, QTd, QTcd and MDA decreased, E/A,SOD and GSH Px increased in the Simvastatin and control groups. Blood lipid,DBP,LVEDS,LVEDd and LVEF did not change before drug treatment and 8 months after that in both groups. Despite SBP, he ratio of these changes in Simvastatin group was greater than those in control group, Conclusions On the basic treatment for patients with diastolic heart failure, Simvastatin can improve cardiac function and decrease QT dispersion by decreaseing oxygen free radicals.
出处
《海南医学》
CAS
2007年第11期7-8,10,共3页
Hainan Medical Journal
关键词
辛伐他汀
舒张功能不全
心功能
QT离散度
氧自由基
Simvastatin
Diastolic Heart Failure
Cardiac function
QT dispersion
Oxygen free radical
