摘要
目的建立慢性阻塞性肺疾病(COPD)和支气管哮喘(以下简称哮喘)支气管舒张反应曲线,探讨COPD和哮喘大、小气道扩张的特点。方法动态观测2004年5月至2005年8月中山大学附属第五医院收治的COPD和哮喘患者吸入福莫特罗前后肺通气功能的变化。结果COPD患者吸入福莫特罗后,第1秒用力呼气量(FEV1)和用力肺活量(FVC)的支气管舒张反应曲线在15min内升高,120min后开始下降,1秒率(FEV1/FVC)支气管舒张反应曲线呈波浪样变化,呼出50%肺活量时最大呼气流量(FEF50)与最大呼气中段流量(FEF75/25)的支气管舒张反应曲线在30min内升高后即开始下降;FEV1,FVC,FEF50随时间点变化的拟合二次曲线模型方程差异有显著性意义(P<0.05)。哮喘患者FEV1,FVC,FEV1/FVC,FEF50,FEF75和FEF75/25的支气管舒张反应曲线在15～30min内升高明显,120min后开始下降;FEV1,FEV1/FVC,FEF75/25随时间点变化的拟合二次曲线模型方程差异有显著性意义(P<0.05)。结论COPD与哮喘患者大、小气道舒张具有不同的特点,支气管舒张反应曲线可以用来鉴别两者。
Objective To set up bronchodilation curve in patients with chronic obstructive pulmonary disease（COPD） or asthma and investigate the features of large and small airways dilation. Methods Pulmonary functions of 44 COPD and 68 asthma patients were determined before and after inhaling Formoterol, Results The curves of FEV; and FVC rose at 15 minutes after inhaling Formoterol and then declined at 120 minutes post-formoterol in patients with COPD. The curves of FEV1/FVC and FEF75 presented as a wave form,and the curves of FEF50 and FEF75/25 rose at 30 minutes and declinod after 30 minutes. The fitting quadr-curves model equations for FEV1 , FVC and FEF50 over time were statistically significant（P〈0.05 ）. In the asthmatic patients, the curves of FEV1, FVC, FEV1/FVC, FEF50, FEF75 and FEF75/25 rose at 15-30 minutes after inhalation of Formoterol and then declined at 120 minutes. The fitting quadr-curves model equations for the lung function parameters of FEVl , FEVl/FVC and FEF75/25 over time were statistically significant（P〈0.05 ）. Conclusion There are some different characteristics during the large and small airways dilation between patients with COPD and those with asthma. Bronchodilation response curve can be used to discriminate COPD and asthma.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第21期1670-1673,共4页
Chinese Journal of Practical Internal Medicine
基金
珠海市科技计划项目(20052028)
关键词
肺疾病
慢性阻塞性
哮喘
肺功能
曲线
Pulmonary disease, chronic obstructive
Asthma
Pulmonary function
Curve
