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62例2型糖尿病患者血IGF-1、IGFBP-3水平测定及与糖尿病视网膜病变的相关性 被引量:2

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摘要 用ELASA法对62例2型糖尿病患者(糖尿病组)及30例健康人(对照组)进行血胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)及空腹血糖(FPG)、糖化血红蛋白(HbA1c)水平测定,分析IGF-1、IGFBP-3与糖尿病视网膜病变(DR)的相关性。结果糖尿病组血IGF-1、IGFBP-3水平显著低于对照组(P<0.01、0.05),其中合并增殖性DR者显著高于非增殖性DR者(P<0.05);血IGF-1与IGFBP-3水平呈正相关(r2=0.71,P<0.01),糖尿病组IGF-1与HbA1c呈正相关(r2=0.31,P<0.01)。认为IGF-1及IGFBP-3可能参与了糖尿病DR的发生和发展。
出处 《山东医药》 CAS 北大核心 2007年第29期47-48,共2页 Shandong Medical Journal
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