摘要
人巨细胞病毒(human cytomegalovirus,HCMV)在老年人群中感染普遍。现已发现,HCMV感染可加速老年人群免疫衰老的进程。免疫风险表型(immunological risk phenotypes,IRP)是一组评价机体免疫功能的指标,与HCMV等病毒感染密切相关;该指标的变化不仅可以反映老年人群的免疫状态,而且通过对其指标,如CD4/CD8比例、CD28分子的监测可以提前预测疾病的发生,为延缓免疫衰老、免疫干预等提供客观依据。因此,该指标日益受到广泛关注。HCMV长期潜伏感染可导致机体的免疫功能低下,尤其对于老年人来说,HCMV感染通常可以导致多项IRP指标的改变,这种改变有可能是引起多种老年性疾病的原因。本文就近年来关于HCMV感染与IPR之间的关系研究进展情况作一综述。
Human cytomegalovirus（HCMV） infection is ubiquitous in the elderly. It may accelerate the course of immunosenescence. Immunological risk phenotypes（IRP） as a group of index for individual’s immune function is significantly associated with viral infection such as HCMV associated infection. The index can not only represent the immune state in the eldly, but also may forecast the occurance of the disease and may provide the objective evidence to interfere immunologically so that the immunosenescence could be delayed. As a result, the index increasingly gets more attention. HCMV long-term latent infection can decrease the immune function especially in the elderly. The infection can induce IRP which may be the cause of most diseases in the elderly. The relationship between the HCMV infecton and IRP is discussed.
出处
《生命科学》
CSCD
2007年第5期543-546,共4页
Chinese Bulletin of Life Sciences
基金
安徽省"十五"生物医药重大科技专项项目资助(01303003)
关键词
HCMV感染
免疫衰老
免疫风险表型
HCMV infection
immunosenecence
immunological risk phenotypes
