摘要
目的:观察单纯性肥胖者进餐前后自主神经活动特征,探讨其与肥胖者胃动力异常的关系.方法:采用十二导联动态心电记录仪,记录102例单纯性肥胖者和49例正常体重健康志愿者,餐前和餐后1 h心电信号,进行心率变异分析.结果:餐前肥胖组RR间期标准差的平均值(SDNNindex)和RR间期差值的均方根(RMSSD)、高频功率(HF)、超低频功率(ULF)显著高于对照组(87.31±15.64 ms,82.50±67.19 ms.31 168.60±6361.00 ms^2,22 814.17±4083.90 ms^2 vs 79.38±12.28 ms,56.04±10.15 ms.12 999.4±5995.00 ms^2,16 595.75±5615.09 ms^2,P<0.05,P<0.01),L/H显著低于对照组(0.65±0.43 vs 0.99±0.42,P<0.01);餐后肥胖组RMSSD,HF显著高于对照组(87.90±57.21 ms.36 158.56±6361.00 ms^2 vs 39.25±11.15 ms.6570.50±5995.80 ms^2.P<0.01),SDNNindex,ULF,LF/HF显著低于对照组(79.59±32.54 ms.14135.7±8083.90 ms^2,0.63±0.34 vs 141.67±10.28 ms.22 785.63±9615.20 ms^2,1.11±0.32,P<0.01);对照组餐后SDNNindex,ULF较餐前升高,RMSSD,HF较餐前降低,LF/HF餐后较餐前升高;肥胖组SDNNindeX,ULF较餐前降低,RMSSD,HF较餐前升高;LF/HF餐后和餐前无差异(P>0.05).结论:单纯性肥胖者餐前餐后均存在自主神经活动异常,自主神经活动异常可能是导致肥胖者胃动力亢进的主要原因之一.
AIM： To observe the characteristics of autonomic nervous activity before and after meals in individuals with obesity, and to discuss the relationship between autonomic nervous activity and gastric motility. METHODS： One hundred and two subjects with obesity and 49 controls were studied with 24-hours dynamic electrocardiography, and the electrocardiograms were recorded 1 hour before and after meals. Heart rate variability was analyzed. RESULTS： Before a meal, SDNN index, RMSSD,high frequency power （HF） and ultra-low frequency power （ULF） in subjects with obesity were higher than those in control subjects （87.31 ±15.64 ms, 82.50 ± 67.19 ms, 31 168.60 ±6361.00 ms^2, 22 814.17 ±4083.90 ms^2 vs 79.38± 12.28 ms, 56.04± 10.15 ms, 12 999.4 ± 5995.00 ms^2, 16 595.75 ± 5615.09 ms^2, P 〈 0.05, P 〈 0.01）, and L/H was lower in subjects with obesity than in the controls （0.65 ± 0.43 vs 0.99±0.42, P 〈 0.01）. After a meal, RMSSD and HF were higher in subjects with obesity than in the controls （87.90 ± 57.21 ms, 36 158.56± 6361.00 ms^2 vs 39.25 ± 11.15 ms, 6570.50 ± 5995.80 ms2, P 〈 0.01）. SDNNindex, ULF and low-frequency power （LF）/HF were lower in the subjects with obesity than in the controls （79.59± 32.54 ms, 14 135.7± 8083.90 ms2, 0.63± 0.34 vs 141.67± 10.28 ms, 22 785.63 ± 9615.20 ms2, 1,11 ± 0.32, P 〈 0.01）. Compared with before meals, SDNNindex, ULF and LF/ HF after meals increased significantly in the controls （P 〈 0.01）, and RMSSD and HF decreased markedly （P 〈 0.01）. In subjects with obesity, after meals, SDNNindex and ULF decreased, and RMSSD and HF increased significantly （P 〈 0.01）; LF/HF did not differ between before and after meals （P 〉 0.05）. CONCLUSION： In fasting and post-prandial states, people with obesity have abnormal autonomic nervous activity. This may be one mechanism of hypermotility in obesity.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第27期2955-2957,共3页
World Chinese Journal of Digestology
基金
河北省科学技术厅2006河北省科学技术研究与发展指导计划资助项目
No.062761896.~~
关键词
单纯性肥胖
自主神经
心率变异
心电记
录仪
Obesity
Autonomic nervous activity
Heart rate variability
Electrocardiography
