摘要
肝硬化失代偿期并发的脾功能亢进和血细胞减少,互为因素,相互影响,是造成病情进展的重要原因.部分患者脾脏切除后,外周血细胞不仅无增加,反而出现进行性下降的表现,表明在肝硬化时外周血细胞减少,除了脾脏及病毒因素外也存有其他因素参与这一病程.各种免疫细胞因子变化、造血干细胞的状态都可能参与和调节肝硬化失代偿期外周血细胞减少这一过程,阐释肝硬化失代偿期外周血细胞减少成因机制对治疗意义重大,值得深入研究.
Decompensated cirrhosis complicated with hypersplenism and hypocytosis are related and influence each other, with the latter being an important aggravating cause of the disease. Peripheral blood cells of some patients with cirrhosis after splenectomy not only do not increase, but actually decrease gradually. These results indicate that declining peripheral blood cells in patients with cirrhosis may be the result of factors in addition to the spleen and viral factors. Current research shows that various immune cytokine changes and hematopoietic stem cells states are likely to be involved and regulate the process of decreasing the number of peripheral blood cells in decompensated cirrhosis. It is suggested that inducing peripheral blood cells to cause a decrease in decompensated cirrhosis is worthy of more indepth study as a potential therapy.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第27期2861-2864,共4页
World Chinese Journal of Digestology
基金
国家自然科学基金项目
No 30670961~~
关键词
肝硬化
脾功能亢进
造血干细胞
免疫反应
Hepatic cirrhosis
Hypersplenism
He-mopoietic stem cells
Immune reaction
