摘要
文中针对用Ｓ－Ｂ１工艺路线生产维生素Ｂ１工艺过程中的关键问题——乙酰嘧啶中间产物收率过低（６０％左右），研究了原料配比、水用量和乙酰嘧啶在水中的溶解度对总收率的影响，以及工艺操作条件对生成乙酰嘧啶的反应特性的影响。并用统计方法对实验数据进行了处理，研究了操作过程对总收率的影响。结果表明，相对于１ｍｏｌ缩醛，甲醇钠、盐酸乙脒的最佳使用量为２．７６ｍｏｌ和３．１ｍｏｌ。而且在５５～６５℃区间的升温时间应控制在最佳。这样，总收率依缩醛计可以提高５％～１０％。
To improve the recovery of acetyl pyrimidine intermediate which is the key problem for production of VB 1 in S B 1 process, the effects of raw material, consume of water and solubility of acetyl pyrimidine in water were studied. The effect of process conditions on reaction characteristics of product of acetyl pyrimidine was also researched. The experiment data were treated with statistical method. The results show that the optimum quantity of sodium methonate and acetamidine hydrochloride corresponding to 1 mol α dimethoxy methy1 β methoxy acrylonitrile is 2.76 mol and 3.1 mol respectively. Andthe raise time of temperature in 55￣65℃ inter region has to be controlled in optimum.The recovery ratio can be increased 5%￣10% or so.
出处
《清华大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
1997年第6期43-45,共3页
Journal of Tsinghua University(Science and Technology)
关键词
维生素B1
乙酰嘧啶
合成
工艺
vitamin B 1
acetyl pyrimidine
2 methyl 4 amino 5 acetamide methylene pyrimidine
