摘要
骨巨细胞瘤(giant cell tumor of bone,GCT)是一种常见骨肿瘤,由于其高复发率和强侵袭性,备受临床骨科工作者的关注。骨巨细胞瘤血管生成是近年来研究热点,实体瘤的发生、发展及转移与肿瘤的血管生成密切相关;细胞外基质降解在肿瘤的浸润和转移中起到关键作用;肿瘤细胞的分化凋亡障碍与无限增殖能力是肿瘤细胞的重要生物学特征。骨巨细胞瘤生物大分子研究的不断深化对判断GCT的预后及指导治疗有重要意义。
Giant cell tumor of bone is a kind of common bone invasion.Recently,tumor vessel angiogenesis has been the warm tumor,which has characteristics of high recurrence rate and spot of research.Genesls,development and metabasis of solid tumor have close relationship with tumor vessel angiogenesis; extracellular matrix degradation is the key point for tumorous infiltration and metabasis;the significant biology characteristic of tumor cell is the disorder of tumor cell differentiation and apoptosis.The correlated research has very important significance for judging GCT prognosis and guiding therapy.
出处
《中国医药导报》
CAS
2007年第11Z期10-12,共3页
China Medical Herald
关键词
骨巨细胞瘤
生物大分子
肿瘤细胞
增殖
凋亡
Giant cell tumor of bone
Biomacromolecule
Tumor cell
Hyperplasty
Apoptosis
