摘要
目的：比较培氟沙星与头孢曲松对细菌感染的疗效。方法：用培氟沙星注射液治疗细菌感染５０例（男性２６例，女性２４例；年龄５８±ｓ１３ａ），剂量４００～８００ｍｇ／次，加入５％葡萄糖液１００ｍＬ中静脉滴注，每日２次。另用头孢曲松２ｇ加５％葡萄糖液２５０ｍＬ中静脉滴注，每日１次，治疗５０例作对照。２组用药天数均为９±３ｄ（４～１８ｄ）。结果：培氟沙星组临床有效率为８２％，细菌阴转率为８０％，对照组分别为７８％和７５％。２组无明显差异（Ｐ＞０．０５），且均未发现有严重不良反应。结论：培氟沙星与头孢曲松治疗细菌性感染疗效无差别，是一种抗菌作用强、对临床难治和严重的感染有满意疗效的抗菌药物。
AIM: To compare the effectiveness of pefloxacin in treatment of patients with multiplicate bacterial infections. METHODS: Fifty patients (M 26, F 24, age 58±s 13 a) with multiplicate bacterial infections were treated with pefloxacin injection. Pefloxacin was given 400-800 mg in 5% glucose 100 mL, iv, gtt, bid. Fifty patients of control group were treated with ceftriaxone 2 g in 5% glucose 250 mL, iv, gtt, qd. All the patients (100 patients) were treated for 9±3 d(4-18 d). RESULTS: The effective rate with pefloxacin was 82%, and rate of bacteria becoming negative was 80%. It was 78% and 75% respectively in control group. CONCLUSION: Pefloxacin is a high effective antibacterial and can get satisfactory results in serious and refractory infections.
出处
《新药与临床》
CSCD
北大核心
1997年第3期144-146,共3页
关键词
培氟沙星
头孢曲松
细菌感染
pefloxacin
ceftriaxone
bacterial infection
