期刊文献+

老年心力衰竭患者血浆B型钠尿肽的变化及其临床意义

下载PDF
导出
摘要 目的:探讨老年心力衰竭患者血浆B型钠尿肽(BNP)水平变化及其在老年心力衰竭患者中的临床应用价值。方法:将不同病因造成的68例老年心力衰竭患者依据NYHA心功能分级,采用ELISA法于入院时、治疗后进行血浆BNP水平检测,并行超声心动图检查。32例健康成人为对照组。结果:各心功能不全患者血浆BNP水平均高于对照组(P<0.01);I^IV级患者血浆BNP水平逐步增加(P<0.01);LVEDD≤55mm的血浆BNP显著低于LVEDD>55mm者(P<0.01);LVEF≤40%的血浆BNP显著高于LVEF>40%者(P<0.01)。治疗前后血浆BNP水平比较具有显著性差异(P<0.05)。不同病因所致同级心衰BNP水平中,冠心病组最高,心率失常组最低。结论:老年心力衰竭患者血浆BNP水平升高是早期心功能受损的敏感指标,对老年心力衰竭患者的快速诊断、治疗及心衰严重程度的迅速判断有非常重要的临床价值。
出处 《数理医药学杂志》 2007年第5期654-655,共2页 Journal of Mathematical Medicine
  • 相关文献

参考文献7

  • 1Sagenlla GA.Measurement and significance of circulating natriuretic peptides in cardiovascular disease.Clin Sci,1998,95(5):519-529. 被引量:1
  • 2Alan S,Malsel MD,Padma KY,et al.Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.N Engl J Med,2002,347(3):161-167. 被引量:1
  • 3Howie JN,Caldwell MA,Dracup K.The measurement of brain natriuretic peptide in heart failure:precision,accuracy,and implications for practice.AACN Clin Issues,2003,14(4):520-531. 被引量:1
  • 4任明,柳茵,刘维军,李琳.慢性心力衰竭患者血浆脑利钠肽、内皮素-1水平与心功能状态的关系[J].中国现代医学杂志,2006,16(19):3023-3026. 被引量:16
  • 5Dessi-Fulgheri P,Sarzani R,Rappelli A.Role of the natriuretic peptide system in lipogenesis/lipolysis.Nutr Metab Cardiovasc Dis,2003,13(4):244-249. 被引量:1
  • 6Seino Y,Ogawa A,Yamashita T,et al.Application of NT-proBNP and BNP measurements in cardiac care:a more discerning marker for the detection and evaluation of heart failure.Eur J heart Failure,2004,6(3):295-300. 被引量:1
  • 7Mair J,Lercher H,Puschendorf B,et al.The impact of cardiac natriuretis pptide determination on the diagnosis and management of heart failure.Clin Chem Lab Med,2001,39(7):571-588. 被引量:1

二级参考文献13

  • 1BITTNER V,WEINER D,YUSUF S,et al.Prediction of mortality and morbidity with 6-minute walk in patients with left ventricular dysfunction[J].JAMA,1993,270(14):1702-1707. 被引量:1
  • 2SUDOH T,KANGAWA K,MINAMINC N,et al.A new nutrioretic peptide in porcine brain[J].Nature,1985,332:78-81. 被引量:1
  • 3MAEDA K,TSUTAMOTO T,WADA A,et al.Plasma brain natricuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction[J].Am Heart J,1997,135:825-831. 被引量:1
  • 4CHEUNG BM,MBB CHIR,KUMANA CR,et al.Natriuretic peptides relevance in cardiovascular disease[J].JAMA,1998,280(23):1983-1984. 被引量:1
  • 5LEVIN ER,GARDNER DG,SAMSON WK,et al.Natriuretic peptide[J].N Engl Med,1998,339:321-327. 被引量:1
  • 6CARGILL RI,BARR CS,COUTIE WJ,et al.C-type natriuretic peptide levels in cor pulmonale and in congestive heart failure[J].Thorax,1994,49(12):1247-1249. 被引量:1
  • 7YANAGISAWA M,KURIHARA H,KIMURA S,et al.A novel potent vasoconstrictor peptide produced by vascular endothelial cells[J].Nature,1988,332(6163):411. 被引量:1
  • 8YOSHIMURA M,YASUE H,OKUMURA K,et al.Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure[J].Circulation,1993,87:464-469. 被引量:1
  • 9MOEDA K,TAKAYOSHI T,WADE A,et al.High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure[J].J Am Coll Cardiol,2000,36(5):1587-1593. 被引量:1
  • 10BIANCIOTTI LG,DE BOLD AJ.Modulation of cardiac natriuretic peptide gene expression following endothelin type A receptor blockade in renovascular hypertension[J].Cardiovasc Res,2001,49:808-816. 被引量:1

共引文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部