摘要
目的探讨他汀类药物联合辅酶Q10对慢性心力衰竭的治疗作用。方法将84例充血性心力衰竭患者随机分为辛伐他汀组(n=42)和对照组(n=42)。在常规治疗的基础上辛伐他汀组加用辛伐他汀和辅酶Q10,辛伐他汀起始剂量5mg/d,4周后增至10mg/d,辅酶Q1010mg,1天3次。结果治疗12周后,辛伐他汀组较对照组血浆总胆固醇和低密度脂蛋白水平降低,心功能改善,左室射血分数提高(P<0.01),血浆肿瘤坏死因子α(TNF-α)和白介素-6(IL-6)水平显著降低(P<0.01)。结论辛伐他汀可以显著改善心力衰竭患者的心功能和血管内皮功能,提示他汀类药物可用于治疗充血性心力衰竭。
Objective To research therapeutic effcets of simvastatin and ceenzyme Q10 in treatment of congestive heart failure. Methods Eighty-four patients with congestive heart failure were randomly divided into two groups：one group （ n = 42） received simvastatin and ceenzyme Q10 ;the other group（ n =42） received regular treatment. On the basis of regular treatment,the initial dose of simvastatin was 5 mg/d and increased to 10mg/d after 4 weeks,and the dose of ceenzyme Q10 was 10mg,three times a day. Results After 12 weeks,the group receiving simvastatin exhibited a reduction in plasma chlolesterol and LDL compared to the contrast group. NYHA cardiac function class in simvastatin group was improved ,and left ventricular ejection fraction（LVEF） was increased in patients treated with simvastatin[ （39. 07 ±3.52） % vs （34. 07 ± 3.14） %, P 〈 0.01 ]. The plasma concentration of TNF-α and IL-6 were significant decreased in simvastatin group （P 〈 0. 01 ）. Conclusions Simvastatin can improve cardiac and endothelial function in patients with congestive heart failure. It suggests that simvastatin may have therapeutic benefits in congestive heart failure.
出处
《中国厂矿医学》
2007年第5期465-466,共2页
Chinese Medicine of Factory and Mine
