摘要
目的:了解生长激素缺乏时大鼠正畸牙周组织的改建特征,探讨rh-GH对成年大鼠牙周组织受正畸力后改建的影响。方法:选用30只7周龄雌性SPF级Wistar大鼠,随机均分为对照组、摘除卵巢组(NS组)r、h-GH组。手术方法建立成年及正畸牙移动动物模型,测量3组大鼠牙齿移动距离并进行牙齿牙周联合切片的组织学观察。结果:无论是2周处死的大鼠还是4周处死的大鼠,第一磨牙移动距离均为NS组最大r、h-GH组次之、对照组最小,各组间差异有统计学意义,P<0.05;rh-GH能减轻正畸治疗带来的牙周膜损伤和炎症,抑制牙槽骨、牙骨质乃至牙本质的异常吸收,利于骨改建过程平衡的恢复。结论:rh-GH可明显抑制成年大鼠正畸牙齿的移动,利于成年大鼠牙周组织受正畸力后的改建及骨改建过程平衡的恢复。
Objective： To investigate the effect of rh-GH on experimental remodeling of powered periodontal tissues during orthodontic tooth movement in adult rats. Methods： Thirty female 7 week old SPF Wister rats were randomly divided into three groups： the control group, the NS group, the rh-GH group. The orthodontic tooth movement models were established by operation. The distance of tooth movement was measured and the periodontal tissues were histologically studied. Results： The distance of tooth movement of the control group was the shortest, that of the NS group was the longest, and that of the rh-GH groual was shorter than that of the NS group and longer than that of the control group in the three groups. All the results had statistical significances, rh-GH significantly improved the periodontal membrane condition and may promote alveolar bone forming and inhibit bone resorption. Conclusion： rh-GH may slow the tooth movement of adult rats and improve the remodeling of powered periodontal tissues.
出处
《山东大学学报（医学版）》
CAS
北大核心
2007年第9期899-902,共4页
Journal of Shandong University:Health Sciences
基金
山东省医药卫生科技发展计划资助项目(2005HZ038)
山东省自然科学基金资助项目(Y2004C13)
