摘要
Alu家族是灵长类动物特有的且是最重要的短散在元件(short interspersed elements,SINEs),经过6千5百万年的进化,Alu序列在基因组中约有120万份拷贝,占基因组的10%以上。Alu家族在基因组中有很多功能,如介导重组、基因插入和删除、甲基化和A-to-I的编辑作用、调控转录和翻译、选择性剪接等等。Alu家族的变异与疾病和进化存在密切关系。
Alu family is the most important primate-specific short interspersed elements （SINEs）. Over the last 65 million years, Alu repeats have propagated into a big family, which has about 1.2 million copies and comprises over 10% of the human geome. Alu repeats have many functions such as recombination, retrotranspositionmediated insertion and deletion, DNA methylation, A-to-I editing, regulation of transcription and translation, alternative splicing and so on. The mutation of Alu repeats is connected to the diseases and evolution.
出处
《细胞生物学杂志》
CSCD
2007年第5期641-645,共5页
Chinese Journal of Cell Biology
