摘要
目的:建立比浊法测定阿奇霉素制剂的效价。方法:肺炎克雷伯菌为实验菌,加菌量1.5%～2.5%,(37±0.5)℃培养3.5～4.5 h 测定。结果:抗生素线性浓度为0.96～2.34 u·mL^(-1),高、中、低3种浓度的平均回收率分别为101.6%,99.4%与101.7%;RSD 分别为3.3%,1.4%,2.3%(n=3)。结论:本方法方便、快速、灵敏,可信限率低,结果准确,精密度好,可作为阿奇霉素原料及其制剂效价的测定方法。
Objective：To establish a turbidimetric method for tiones. Method：The test organism was Klebosiella Pneumoniae. moniae inoculated with a 1.5% - 2. 5% ratio, at （ 37 ± 0.5 ） ℃ -2. 34 u · mL^-1, the average recovery for high, media and low RSD were 3.3%, 1.4% and 2. 3% （n = 3 ）. Conclusion：The determine azithromycin preparations. the content determination of azithromycin prepara- Adjusted bacterium suspension of KlebosieUa Pneu- for 3.5 - 4. 5 h. Results： The linear range was 0. 96 concentration were 101.6% ,99. 4% and 101.7% , method is seneitive, rapid, prescion and feasible to
出处
《药物分析杂志》
CAS
CSCD
北大核心
2007年第10期1561-1564,共4页
Chinese Journal of Pharmaceutical Analysis
关键词
效价
比浊法
阿奇霉素
potency
turbidimetric method
azithromycin
