摘要
采用Wistar大鼠腹膜炎模型，给予己酮可可碱（PTX）肌注后，血液中肿瘤坏死因子浓度和CDL+11b阳性细胞阳性率显著下降；肺泡灌洗液中白细胞数和蛋白含量也有减少；动物存活率提高；肺组织含水量无变化．结果表明，PTX具有防止脓毒血症早期肺损伤的作用．
The author explored the protection effect of pentoxiffylin (PTX) on early lung injury in the animals with severe abdominal sepsis. The result is showed as follows: The septic animal treated with PTX revealed significant fall of the level of serum tumor necrosis factor (TNF) and the proportion of positive CD11b+ cells in circulating leukocytes compared with the control septic animals. The number of neutrophils and the content of protein in the fluid from levaged lung were lower in the animals treated by PTX than in the control animals. But no siginificant dmerence in lung wet-dry ratio was found between the PTX group and the control group The experiment shows that PTX may improve the survival of the septic animals. The result of the experiment demonstrates that PTX plays a role in protection of lung from early injury in abdominal sepsis.
出处
《苏州医学院学报》
1997年第2期206-207,共2页
Acta Academiae Medicinae Suzhou
关键词
成人
呼吸窘迫综合症
己酮可可碱
腹膜炎
Tumor necrosis factor
Adult respiratory distress
syndrom pentoxiffylin
