摘要
目的:连续观察髋关节置换术后人工假体周围早期骨量变化,为假体技术完善和骨量丢失的药物预防提供依据。方法:选择2004-01/2006-01在商丘市第一人民医院骨科住院进行人工髋关节置换术患者55例,均在术后1周、3、6和12个月时用双能X线骨密度仪进行人工假体周围骨量测定(髋臼假体区,采用Wilkinson4区法,即R1、R2、R3、R4区;股骨柄假体区,采用Gruen方法分7个测量兴趣区,即ROI①、②、③、④、⑤、⑥和⑦区),上述采集数据与同一患者未置换部位比较。结果:55例患者均进入结果分析。①髋臼区骨密度:髋臼区术侧与健侧术后1周检查时各扫描区域骨密度检测值分布接近(P均>0.05),但在术后3、6和12个月检查中,术侧R1、R2和R3区骨密度全部测试结果均明显低于健侧同部位检测值(P均<0.05～0.01),两侧间R4区骨密度测试结果无明显区别(P>0.05)。②股骨区骨密度:术后1周时术侧各扫描区域骨密度检测值与健侧分布接近(P均>0.05),在术后3、6和12个月检查中,术侧ROI①、②、③、⑥和⑦区骨密度全部测试结果均明显低于健侧同部位检测值(P均<0.05～0.01),两侧间ROI④和⑤区骨密度大部分测试结果无明显区别(P均>0.05)。结论:髋关节置换术患者人工假体周围早期骨量丢失以R1、R2、R3区和ROI①、②、③、⑥、⑦区较为明显,并多发生术后3～12个月。
AIM： To continuously evaluate the early change of periprosthetic bone mineral density （BMD） after total hip arthroplasty, and provide the effective data for prosthetic technological improvement and drug prevention of bone loss. METHODS： A total of 55 inpatients underwent total hip arthroplasty in the Department of Orthopedics at Shangqiu First People＇s Hospital between January 2004 and January 2006, were selected. Periprosthetic BMD of 11 regions of interest （ROI： 4 acetabular prosthetic areas by Wilkinson＇s method and 7 femoral pedicle areas by Gruen＇s method） was determined with dual energy X-ray absorptiometry at the Ist week and the 3% 6^th, 12^th months after operation. Then the collected data were compared with that in non-operation side of the same patient. RESULTS： All of 55 patients were involved in the result analysis. There were no significant differences of BMD between the operation side and non-operation side in both femur and acetabulum at the Ist week after operation （P 〉 0.05）. BMD in acetabular R1, R2, R3 and femur ROI ①,②,③,⑥,⑦ of operation side was distinctly lower to that in non-operation side （P〈 0.05-0.01）, but BMD in R4 and ROI ④,⑤ had no difference （P〉 0.05） at the 3^th, 6^th, 12^th months after operation. CONCLUSION： The periprosthetic BMD decreases severely in R1, R2, R3 and ROI ①,②,③,⑥,⑦ during 3-12 months after total hip arthroplasty.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第40期8074-8077,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
