摘要
采用免疫组织化学方法，测定人食管正常上皮和癌前病变组织中肿瘤抑制基因Ｒｂ和Ｐ１６蛋白表达。结果：在２５例食管粘膜活检组织中，共发现８例食管正常上皮、１３例基底细胞增生和４例间变。在正常组织未见Ｒｂ和Ｐ１６免疫阳性反应，而基底细胞增生中Ｒｂ和Ｐ１６的免疫阳性反应率分别为１６％和９％，间变均为３３％。提示：食管癌变的早期阶段已发生Ｒｂ和Ｐ１６蛋白表达变化。
The expression of tumor suppressor gene Rb and P16 was determined in human normal esophageal epithelium and precancerous lesions with immunohisto chemical method.Results:of the 25 esophageal mucosa biopsies,8 cases were found with normal esophageal epithelia;13 cases with basal cell hyperplasia and 4 cases with dysplasia.Immunoreactivity for Rb and P16 was not found in normal esophageal epithelium,but in basal cell hyperplasia,positive immunoreactivity for Rb and P16 was found with the rates of 16% and 9%, respectively.In dysplasia,the positive immunoreactivity rates of Rb and P16 were the same with each other (33%).The present results indicated that the expression of Rb and P16 occurred in the early stage of esophageal carcinogenesis.The biological significance of these changes need to be further characterized.
出处
《河南医科大学学报》
1997年第1期30-33,共4页
Journal of Henan Medical University
基金
国家自然科学基金
国家教委留学回国人员专项基金
河南省首批杰出青年科学基金
关键词
食管肿瘤
癌前病变
RB
P16
抑癌基因
esophageal precancerous lesions:tumor suppressor gene
Rb
P16
