摘要
目的:探讨肺结核患者血清透明质酸(HA)、层黏连蛋白(LN)含量的变化及其对治疗的反应性。方法:采用放射免疫分析检测30例健康体检者及82例肺结核患者血清HA、LN含量及活动性肺结核患者治疗前后的变化。结果:活动性肺结核患者血清HA、LN显著增高(P<0.01),而非活动性肺结核患者HA、LN与对照组比较无显著差异;治疗后2个月活动性肺结核患者HA、LN降低,但仍高于对照组。HA、LN值与病程、C-反应蛋白(CRP)及血沉(ESR)值存在相关性,HA与LN结果亦显著相关(P<0.01)。结论:检测血清HA和LN对肺结核患者肺纤维化的早期诊断、病情监测及疗效判断有重要意义。
Objective To study the serum HA and LN level in patients with pulmonary tubereulosis and their response to therapy. Methods Serum HA and LN levels were measured with PdA in：① 42 patients with active pulmonary tuberculosis both before and after 2 months＇ therapy, ②40 patients with non - active pulmonary TB and 330 controls. Results The serum HA and LN level in patients with active pulmonary tuberculosis were significantly higher than those in controls （ P 〈 0.01 ）, while no significant difference could be found between the levels in patients with non - active pulmonary tuberculosis and controls. The serum HA and LN level in patients with active pulmonary tuberculosis dropped after therapy, but were still higher than those in controls. Significant correlation could be found between HA and LN levels （ P 〈 0.01 ）. The HA and LN levels were positively correlated with severity of the disease, ESR and CRP contents. Conclusion The measurement of serum HA and LN is valuable for early diagnosis, monitoring development and assessment of therapeutic effect in patients with pulmonary tuberculosis.
出处
《放射免疫学杂志》
CAS
2007年第5期398-399,共2页
Journal of Radioimmanology
关键词
肺结核
透明质酸
层黏连蛋白
pulmonary tuberculosis, hyaluronic acid, laminin
