摘要
目的:比较小儿麻醉用七氟烷吸入诱导和丙泊酚静脉诱导的临床特点。方法:择期手术的患儿30例,美国麻醉医师协会(ASA)Ⅰ-Ⅱ级,随机分为两组:七氟烷(Sev)组和丙泊酚(Pro)组,分别记录诱导至意识消失的时间,和诱导前、诱导时、插管后即时和插管后1分钟的血压、心率、SpO_2,及诱导时躁动、屏气、喉、支气管痉挛、恶心、呕吐等不良反应。结果:两组患儿意识消失的时间没有显著差异,分别为丙泊酚组(35.5±11.7)s;七氟烷组(38.5±11.4)s。两组诱导和插管后血压与诱导前比较均无明显变化,但心率变化两组相差较大。丙泊酚组与诱导前相比心率显著增加(P<0.05);而七氟烷组心率较诱导前明显下降(P<0.05)。发生躁动七氟烷组显著多于丙泊酚组(P<0.05),分别是46%和20%。两组均未见屏气、喉及支气管痉挛和恶心、呕吐等不良反应。结论:两组在麻醉诱导的时间和有效性、安全性上没有差别。但是丙泊酚静脉诱导心率明显增快;七氟烷吸入诱导患儿躁动相对较多。
Objective： To compare the induction characteristics of sevoflurane inhalation with intravenous propofol in pediatric surgery. Methods： 30 children patients（ ASA physical status Ⅰ and Ⅱ） tmdergoing selective operations were randomly allocated to receive induction by inhalation of sevoflurane or intravenous of propofol. BP,HR and SpO2 were recorded before induction of anesthesia,after induction,immediately after and one minute after tracheal intubation. Time to consciousness loss,restlessness, breathholding, laryngospasm,bronchiospasm,nausea and vomiting were also recorded. Results： The times to loss of consciousness in the group of propofol and group of sevoflurane were （35.5 ± 11.7 ） s and （38. 5 ± 11.4 ） s, respectively. There was no significant difference between the two groups. BPs after induction or tracheal intuhation in both groups,compared with before induction,were no significant change. But the changes in HR were significantly different between two groups（ P 〈0. 05 ）. Compared with before induction,HRs in group of propofol were increased significantly（ P 〈 0. 05）, and HRs in group of sevoflurane were significantly decreased （P 〈 0. 05 ）. Restlesshess was more common during induction with scvoflttrane than propofol（46% vs. 20% ,P 〈0. 05）. No incidence of breathholding,laryngospasm,bronchiospasm,nausea and vomiting were noted in both groups. Conclusion： Both propofol and sevoflurane can he used effectively and safely for induction of anesthesia in pediatric surgery. But heart rate was increased during induction with propofol and Excitatory movement was more common during induction with sevoflurane.
出处
《中国医药导刊》
2007年第5期404-405,共2页
Chinese Journal of Medicinal Guide
关键词
七氟烷
丙泊酚
小儿
麻醉诱导
Sevoflurane
Propofol
Pediatrics
Induction of anesthesia
