摘要
目的通过观察康宁克通A对增生性瘢痕色度值的影响,探讨康宁克通A治疗增生性瘢痕的有效性。方法选择增生性瘢痕患者36例,采用自身对照的方法,在每例患者的病灶处选取部位相近、面积相同的增生性瘢痕两处,分为治疗组和对照组。治疗组：于病灶内注射康宁克通A,连续注射4次,每次间隔2周,每次注射4mg/cm^2。对照组：于病灶内注射等量的2%利多卡因,连续注射4次,每次间隔2周。于注射前及注射后4周用CM-2600d分光测色仪测量瘢痕的色度值,并用温哥华评分量表进行综合评价。结果注射后随访患者1～3个月。治疗组患者的痒、胀、痛等自觉症状减轻,病灶处的充血减轻、颜色变浅,注射后的瘢痕明度（L＊值增大）、红绿色值（a＊值变小）、温哥华瘢痕指数与注射前比较差异有统计学意义（P〈0.01）;对照组注射后与注射前比较色度值的差异无统计学意义（P〉0.05）。注射前后两组间各项色度值变化情况的比较其差异有统计学意义（P〈0.01）。结论康宁克通A可使增生性瘢痕的色度值发生明显变化,因此,是治疗增生性瘢痕有效药物之一。
Objective To investigate the efficacy of Kenacort - A on hypertrophic scar by measuring the chroma value of hypertrophic scar before and after Kenacort - A treatments. Methods Thirty - six patients with hypertrophic scar were enrolled in an own controll study. Two masses of scars taken consecutively on the same area of every patient and the masses of scars were divided into therapy group and control group. The scars in the therapy group were administrated with 1% Kenacort - A injection 4 mg/cm^2 for 4 times injection with 2 weeks intervals. The scars in the control group received equal doses of lidocaine injection for 4 times with 2 weeks intervals. Chroma values of both groups were determined by Spectrophotometer CM - 2600 d before and after treatments at 4 weeks, and Vancouver scar scores were used to synthetically evaluated the scars at the same time. Results All the patients were followed up for 1 to 3 months. Physiological symptoms of itch and aching in therapy group were relieved, hyperaemia of scar tissue were lessened and scar color turned light. The L＊ values increased, the a＊ values and the Vancouver scar scores decreased, which had statistical significance compared with those before treatment （P 〈 0.01）. In control group, the post- treatment chroma values weren＇t statistical significant different from the pre - treatment values （P 〉0.05 ）. There were significant differences between the therapy group and the control groups regarding the changes of every chroma values （P 〈 0.01）. Conclusion Chroma values of hypertrophic scar tissue changed significandy after Kenacort - A treatments, therefore, Kenacort- A is one of the effective drugs for hypertrophic scar.
出处
《中国美容整形外科杂志》
CAS
2007年第5期354-356,共3页
Chinese Journal of Aesthetic and Plastic Surgery
