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2型糖尿病患者一次顿服或分两次服用2mg格列美脲的疗效比较 被引量:6

Comparison of once daily and twice daily administration of glimepiride with same total dosage in type 2 diabetes
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摘要 126例2型糖尿病患者1:1随机分组,每日服用格列美脲2 mg(1次服用或分2次服用)。测空腹和三餐后2h血糖,计算它们的极差和标准差;检测HbA_(1C)。结果显示两种服用方式降糖效力相当,但一次服用血糖波动较小。 [Summary] A total of 126 patients with type 2 diabetes mellitus were randomized into two groups: one received glimepiride 1 mg twice daily and the other 2 mg once daily. Fasing blood glucose ( BG), BG 2 h after meals (breakfast, lunch and dinner) and HbA1c were tested, A and standard deviation of the 4 point BG were calculated. It was found that two kinds of administration of glimepiride were equally effective in decreasing BG and once daily ministration could ease better the fluctuation of BG.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第5期427-428,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 格列美脲 糖尿病 2型 血糖控制 血糖波动 Glimepiride Diabetes mellitus, type 2 Blood glucose control Blood glucose excursion
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参考文献7

  • 1Rosenstock J, Samols E, Muchmore DB, et al. Glimepiride, a new once-daily sulfonylurea. A double-blind placebo-controlled study of NIDDM patients. Glimepiride Study Group. Diabetes Care, 1996, 19 : 1194-1199. 被引量:1
  • 2Sonnenberg GE, Garg DC, Weidler DJ, et al. Short-term comparison of once-versus twice-daily administration of glimepiride in patients with non- insulin-dependent diabetes mellitus. Ann Pharmacother, 1997,31:671- 766. 被引量:1
  • 3Veneman TF, Tack CJ, van Haeften TW. The newly developed sulfonylurea glimepiride: a new ingredient, an old recipe.Neth J Med, 1998,52 : 179-186. 被引量:1
  • 4Deerochanawong C, Chandraprasert S, Suthijumroon A, et al. Glimepiride in type 2 diabetes mellitus Thai patients. J Med Assoc Thai, 2001,84 : 1221-1228. 被引量:1
  • 5Shukla UA, Chi EM, Lehr KH. Glimepiride pharmaeokineties in obese versus non-obese diabetic patients. Ann Pharmacother, 2004,38:30-35. 被引量:1
  • 6Langtry HD, Balfour JA, Glimepiride. A review of its use in the management of type 2 diabetes mellitus. Drugs, 1998,55:563-584 被引量:1
  • 7汤,张选红,曾桂雄,黄丽慧,黄民,廖晓星.国产格列美脲片的药代动力学及相对生物利用度[J].中国新药杂志,2003,12(1):47-49. 被引量:3

二级参考文献3

  • 1[1]Langtry HD, Balfour JA. Glimepiride: a review of its use in the management of type 2 diadetes mellitus[J]. Drugs, 1998, 55(4):563 - 584. 被引量:1
  • 2[2]Kremer W, Mueller G, Geisen K. Characterization of the molecular mode of action of the sulfonylurea, glimepiride [J]. Hom Metab Res, 1996, 28 (9): 464 - 468. 被引量:1
  • 3[3]Lehr KH, Damm P. Simultaneous determination of the sulphonylurea glimepiride and its metabolites in human serum and urine by high-performance liquid chromatography after pre-column derivatization[J]. J Chromatogr, 1990, 526(2) :497 - 505. 被引量:1

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