摘要
正常血管通透性的维持有赖于血管内皮细胞屏障的完整性，内皮细胞与内皮细胞间、细胞与基底膜间的连接以及胞内骨架蛋白收缩这3种力量，经蛋白质相互作用，在功能和调节上互相关联。烧伤休克的主要临床特点是低血容量性休克，其主要原因之一是毛细血管扩张，血管通透性增加，毛细血管静水压增加，促进了血浆样液体的渗出，导致血容量锐减。关于内皮细胞屏障功能在烧伤后血管通透性变化中的作用，我们近年来做了一些研究工作。
Massive burn trauma is characterized by hypovolemic shock induced by the loss of plasma from vessels. The major reasons for this systemic microvascular leakage in burns include an increase in vascular permeability triggered by inflammatory mediators and the increase of vascular hydrostatic pressure caused by vessel dilation. The maintenance of normal vascular permeability depends on the integrity of endothelial barrier function regulated by the interaction of intracellular junctions, cell-matrix adhesion and the cytoskeleton contractile force. This review summarizes some recent discovery in endothelial mechanisms during burn-induced vascular hyperpermeability.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2007年第5期324-326,共3页
Chinese Journal of Burns
基金
国家重点基础研究发展规划(2005CB522601)
