摘要
目的:了解陕西地区淋球菌对抗生素的耐药性及产β-内酰胺酶淋球菌(PPNG)的流行状况。方法:采用琼脂稀释法测定4种抗生素对102株淋球菌的最低抑菌浓度(MIC);采用纸片酸度定量法测定PPNG菌株。结果:淋球菌对青霉素、环丙沙星、大观霉素及头孢曲松的耐药率分别为85.29%、94.12%、3.92%、0%。检出25株(24.51%)PPNG菌株。结论:头孢三嗪、大观霉素仍可作为陕西地区治疗淋病的首选用药,但淋球菌对青霉素及环丙沙星耐药率较高。
OBJECTIVE： To study the resistance of neissefia gonorrhoeae to antibiotics and the prevalence of penicillinase- producing neissefia gonorrhoeae （PPNG） in Shanxi area. METHODS： Minimum inhibitory concentrations （MICs） of penicillin G, ciprofloxacin, spectionmycin and ceftfiaxone against 102 strains of neissefia gonorrhoeae were determined by agar dilution. The PPNG strains were determined by paper acidometfic method. RESULTS： The rates of neissefia gonorrhoeae strains resistant to penicillin G, ciprofloxacin, spectionmycin and ceftfiaxone were 85.29 %, 94.12 %, 3.92%, and 0%, respectively. 25 （24.51%） PPNG strains had been detected. CONCLUSION： Ceftfiaxone and spectinomycin could be considered as the first choice in treating patients with gonorrhea. Neissefia gonorrhoeae strains have are highly resistant to penicillin and ciprofloxacin.
出处
《中国医院用药评价与分析》
2007年第5期359-361,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
淋球菌
最低抑菌浓度
耐药性
Neisseria gonorrhoeae
MIC
Drug resistance
