摘要
目的:观察柔肝消饮对肝硬化大鼠肝组织病理形态学和血清、肝组织白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)含量的影响。方法:采用复合因素造模法复制肝硬化大鼠模型,以复方鳖甲软肝片为对照,观察柔肝消饮高、低剂量对肝硬化大鼠肝组织病理形态学、血清和肝组织IL-1β、IL-6、TNF-α含量的影响。结果:与正常组比较,模型组大鼠出现肝小叶损害,纤维组织增生,假小叶形成,血清IL-1β、IL-6、TNF-α含量和肝组织IL-6、TNF-α含量均明显升高(P<0.01或P<0.05);与模型组比较,各治疗组肝脏病理损害较轻,血清IL-1β、TNF-α含量和肝组织IL-6、TNF-α含量均有明显下降(P<0.01或P<0.05);与对照组比较,高剂量组血清IL-6含量明显降低(P<0.05)。结论:柔肝消饮能显著下调肝硬化大鼠血清IL-1β、IL-6、TNF-α水平和肝组织IL-6含量,具有减轻肝硬化炎症损害,改善肝组织病理形态学作用。
To observe the effect of Rougan Xiaozheng Yin on hepatic pathological histology and the content of IL-1β、IL-6 and TNF-α in serum and liver tissue of cirrhosis rats.Methods： The model of cirrhosis rats was established by composite factor,compared with Fufangbiejiaruangan tablet,to observe the effect of Rougan Xiaozheng Yin on hepatic tissue pathological histology and the content of IL-1β,IL-6 and TNF-α in serum and liver tissue.Results： Compared with normal group,the normal hepatic lobules were disappeared and fibroplasias formed nodus and false folial in model group,and the content of IL-1β,IL-6 and TNF-α in serum and the content of IL-6,TNF-α in liver tissue increased obviously（P〈0.01 or P〈0.05）.Compared with model group,the pathological lesion of liver in all treatment groups were fewer.The content of IL-1β,TNF-α in serum and the content of IL-6,TNF-α in liver tissue of all treatment group decreased apparently（P〈0.01 or P〈0.05.Compared with control group,the content of IL-6 in serum of high-dose group decreased obviously（P〈0.05）.Conclusion： Rougan Xiaozheng Yin can decrease the content of IL-1β、IL-6 and TNF-α in serum and the content of IL-6 and TNF-α in liver tissue of cirrhosis rats,lighten inflammation damage,and improve pathological histology of liver.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2007年第10期729-731,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
河北省科技攻关计划课题(No.03276196D-7)
关键词
肝硬化
中医药疗法
柔肝消饮
细胞因子
实验研究
Hepatic cirrhosis
TCM therapy
Rougan Xiaozheng Yin
Cell factor
Experimental study
