摘要
本文报道在扶绥县肝癌高低发区儿童的抗-HBc IgM检测,共检测345人,抗-HBc IgM阳性率为11.0%,其中肝癌高低发区分别为10.3%及11.6%,两地无明显差别。性别年龄分布,男女无明显差别。两地皆以9～12岁年龄组抗-HBc IgM阳性率最高,达20.0%左右,这些阳性儿童其抗-HBc IgM多为高滴度,且有肝功能异常,提示这很可能是水平传播的急性乙型肝炎。结合抗-HBc,HBsAg,肝功能三项指标与抗-HBc IgM检测结果比较,两地抗-HBc及HBsAg阳性者的抗-HBc IgM阳性率最高,但肝功能异常率更高,两地分别为53.2%及31.2%,相差非常显著,同时HBsAg阴性者也有较高的肝功能异常率,两地分别为50.0%及30.8%。提示肝癌高低发区除了HBV感染影响肝功能异常者外,还可能有其他损伤肝脏的有害物质存在,特别在肝癌高发区。值得进一步研究。
345 children,in two areas of Fusui county(“High”PHC area and“low”PHC area,respectively),were tested for Anti—HBc IgM.The total prevalence rate was 11.0%.There was no significant difference in the prevalence rate between these two areas and between the two sexes,but there was some difference between the age groups,peaking in the 9～12 years old group(about 20.0%).In most of the anti-HBc IgM positive children,the titer of this antibody was high,and the liver functions abnormal.These facts suggested that there might be a horizontal transmission of acute hepatitis B among the above studied children.The rates of abnormal liver functions in the children population of the two studied areas were high up to 53.2% and 31.2%,respectively.Even among the HBsAg negatives in the two above mentioned populations,the rates of abnormal liver functions were still very high(50.0% and 30.8%,respectively).This suggested that in the two studied areas,especially in the high PHC area,there might be some substances, other than HBV,which were harmful to the liver.
