摘要
目的:观察雷莫司琼预防含顺铂化疗药物所致胃肠道反应的临床疗效和安全性。方法:采用随机自身对照方法,将入选80倒接受含顺铂联合化疗的恶性肿瘤患者,随机分成A、B两组,A、B两组病人于化疗第一周期分别使用甲氧氯普胺及格拉司琼作对照,第二周期均使用雷莫司琼止吐。结果:雷莫司琼预防化疗后呕吐明显优于甲氧氯普胺,其有效率分别为92.5%、42.5%。但雷莫司琼和格拉司琼预防化疗后呕吐无统计学差异,其有效率分别为90.0%、87.5%。结论:雷莫司琼能有效地预防含顺铂化疗药物所致胃肠道反应,与格拉司琼相似,但优于甲氧氯普胺。
Objective： To obeserve the therapeutic effect and adverse reaction of ramosetron in preventing gastrointestinal reaction induced by chemotherapeutic drugs including cisplatin. Method. An self-control study method was adopted , 80 patients with cancer undergoing chemotherapy regimens including cisplatin were divided into group A （ metoclopramide was given in the first cycle and ramosetron in the second cycle）and group B（ granisetron was given in the first cycle and ramosetron in the second cycle）randomly. Result： The effective rates of ramosetron and metoclopramide in preventing vomiting caused by chemotherapy were 92.5% and 42.5%, respectively. The efficacy and safty of ramosetron was superior to that of metoclopramide （ P 〈 0.05）. The effective rates of ramosetron and granisetron in preventing vomiting caused by chemotherapy were 90.0% and 87.5% ,respectively. There was no statisticat difference in the efficacy between ramosetron and granisetron （ P 〉 0.05 ）. Conclusion： Ramosetron is safe and effective in preventing gastrointestinal reaction caused by including cisplatin chemotherapeutic drugs and is similar as granisetron but superior than metoclopramide.
出处
《中国药师》
CAS
2007年第10期1024-1025,共2页
China Pharmacist
关键词
雷莫司琼
甲氧氯普胺
格拉司琼
化疗
胃肠道反应
Ramosetron
Metoclopramide
Granisetron
Chemotherapy
Gastrointestinal reaction
