摘要
青壮年猝死综合征(SUNDS)的病因迄今不明。随着分子遗传学和心脏离子通道研究的深入,SCN5A基因突变已被确定为Brugada综合征、3型长QT间期综合征的最重要病因。本文综述文献,结合项目组研究,介绍SCN5A基因突变与SUNDS发生的相关性。
The etiology of sudden unexplained nocturnal death syndrome （SUNDS） is so far unknown. With the deep research on molecular genetics and cardiac ion channel, The SCNSA mutation was confirmed to be the most important cause of Brugada syndrome and Type 3 Long QT interval syndrome. According to our epidemiologic data and literatures, the relationship between SCNSA gene mutation and the occurrence of SUNDS were illuminated in the text.
出处
《国际内科学杂志》
CAS
2007年第9期556-558,共3页
International Journal of Internal Medicine
基金
国家自然科学基金(30500581)
广东省自然科学基金(05001685)
关键词
青壮年猝死综合征
SCN5A
基因突变
Sudden unexplained nocturnal death syndrome
SCN5 A
Gene mutation
