摘要
目的研究青霉素钠与莪术油葡萄糖注射液配伍的稳定性。方法采用HPLC法测定配伍后6 h内青霉索钠的含量变化,用分光光度法测定莪术油中莪术醇的含量变化,同时观察配伍液的外观、pH值和微粒的变化。结果在4、25和37℃3种温度条件下,6 h内配伍液全部澄明,pH、微粒均无明显变化。青霉素钠的含量>91%,莪术醇含量>94%。结论青霉素钠与莪术油葡萄糖注射液配伍6 h内基本稳定。
AIM To study the compatible stability of benzylpenicillin sodium with zedoary turmeril oil and glucose injection. METHODS The content of benzylpenicillin sodium was determined by RP-HPLC method. The content of curcumenol in zedoary turmeril oil was determined by UV-spectrophotometry at 4℃, 25℃ and 37℃ winthin 6 h, the appearance of the solution was observed and its pH value and number of particles were determined. RESULTS No significant differences were found in terms of the appearance, the pH value and number of particles of the mixed solution , the content of was more than 91% and the content of curcumenol was more than 94%. CONCLUSION The mixture of benzylpenicillin sodium with zedoary turmeril oil and glucose injection is stable at 4℃, 25℃ and 37℃ winthin 6 h after mixing.
出处
《中国临床药学杂志》
CAS
2007年第5期315-317,共3页
Chinese Journal of Clinical Pharmacy
基金
浙江省苍南县科技局科研基金(编号:2003S09)
关键词
青霉素钠
莪术油
稳定性
HPLC
benzylpenicillin sodium
zedoary turmeril oil
stability
HPLC
