摘要
[目的]探讨COX-2、E-cadherin、VEGF在大肠癌中的表达及意义。[方法]采用免疫组织化学Envision法检测85例大肠癌和10例正常大肠黏膜组织中COX-2、E-cadherin、VEGF的表达。[结果]85例大肠癌中COX-2、E-cadherin、VEGF的阳性率分别为77.6%、34.1%和67.1%,和正常大肠黏膜相比有显著差异(P<0.01)。大肠癌中COX-2、VEGF、E-cadherin的表达在不同Dukes’分期、淋巴结转移状态均有显著差异(P<0.01)。E-cadherin和VEGF的表达在不同浸润深度下也均有差异(P<0.05)。E-cadherin与VEGF、COX-2的表达均呈负相关(r=0.28,r=0.41,P<0.01);COX-2与VEGF的表达正相关(r=0.51,P<0.01)。[结论]COX-2、E-cadherin、VEGF在大肠癌的发生、发展中起着重要作用,三者联合检测可为大肠癌恶性程度和预后的判断提供有效证据。
[Purpose] To study the expression of COX-2, E-cadherin and VEGF in colorectal cancer and its significance. [Method] Expression of COX-2, E-cadherin, VEGF was detected in 85 cases with colorectal cancer and 10 cases of normal large intestinal mucosa by Envision imnmnohistochemical method. [Results] The expression of COX-2, E-cadherin and VEGF in 85 cases with colorectal cancer was 77.6%, 34.1% and 67.1% respectively, with significant difference （P〈0.01） compared with the expression of these proteins in the normal mucosa of large intestine. Expression of COX-2, VEGF and E-cadherin was significantly different with Dukes＇ stages and with lymph node metastasis status （P〈0.01）. Expression of E-cadherin and VEGF was significantly different in different depth invasion （P〈0.05）. Ex- pression of E-cadherin was negatively correlated to the expression of VEGF and COX-2 （r=-0.28,r=0.41, P〈0.01）. Expression of COX-2 was positively related to the expression of VEGF（r=-0.51 ,P〈0.01）. [Conclusionl COX-2, E-cadherin and VEGF play an important role in eareinogenesis and development of colorectal cancer. Combined detection can provide valuable evidence for estimation of aggressive degree and prognosis of colorectal cancer.
出处
《肿瘤学杂志》
CAS
2007年第5期403-405,共3页
Journal of Chinese Oncology
基金
温州医学院重大科研项目(Z2005B076)
