摘要
目的观察1型、2型糖尿病患者(DM)外周血胰岛相关自身抗体的阳性率,并分析其可能的临床意义。方法应用ELISA法检测糖尿病患者血清中的谷氨酸脫羧酶抗体(GAD-Ab)、胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA),并与正常人进行比较。结果1型DM组的ICA、IAA、GAD-Ab阳性率均显著高于2型DM组和正常人群组(P<0.01),一种及一种以上抗体阳性率高于单独一种抗体阳性率(P<0.05),2型糖尿病患者中小于30岁组的ICA、IAA、GAD-Ab阳性率明显高于小于50岁组(P<0.05)。结论三种胰岛自身抗体的联合检测有助于型糖尿病的诊断及鉴别诊断。
Objective To explore the presence and clinical significance of pancreatic islet related autoantibodies in patients with diabetes. Methods Three autoantibodies（GAD-Ab,ICA,IAA） in serum were analyzed by using ELISA. Results The positive rate of each autoantibody in type 1 diabetes was higher than that in type 2 diabetes or healthy control （P〈0.01） ,and the combined detection of autoantibody had higher positive rate than one autoantibody alone （P 〈 0. 05）. In type 2 diabetes, the positive rate of three autoantibodies was higher in patients less than 30 years old than patients more than 50 years old （P 〈 0. 05）. Conclusions The combined detection of three pancreatic islet related autoantibodies may contribute to the diagnosis and identification of disbetes.
出处
《齐齐哈尔医学院学报》
2007年第14期1667-1668,共2页
Journal of Qiqihar Medical University
关键词
糖尿病
谷氨酸脫羧酶抗体
胰岛细胞抗体
胰岛素自身抗体
Diabetes mellitus Glutamic acid decarboxylase antibodies Islet cell antibody Insu- lin autoantibodies
