摘要
目的：探讨咪达唑仑靶控输注（TCI）系统用于腰-硬联合麻醉下患者清醒镇静的可行性及其靶控血药浓度。方法：对60例ASAⅠ～Ⅱ级择期行下肢手术的患者，运用警觉、镇静（OAA／S）评分和脑电双频指数（BIS）评估镇静深度。采用咪达唑仑TCI行清醒镇静，以血浆室为靶控目标，确定相应靶控血药浓度及其与BIS相关性，记录不同OAA／S评分时的血药浓度（Cp）、BIS、平均动脉压、心率、脉搏血氧饱和度。结果：适度清醒镇静（OAA／S评分3分）时所需靶控血药浓度为（122．8±20．8）ng·mL^-1.BIS与Cp具有良好的相关性，BIS=-3．28Cp＋355．22（r=-0．8625，P〈0．01）。结论：咪达唑仑TCI系统用于腰-硬联合麻醉患者清醒镇静可控性良好，镇静深度适宜，对血流动力学和呼吸功能无明显影响。
OBJECTIVE： To confirm the feasibility of target - controlled infusion of midazolam on conscious sedation for patients undergoing combined spinal- epidural anesthesia and the needed target- controlled blood concentration. METHODS： Sixty patients undergoing combined spinal - epidural anesthesia were subjected to target - controlled infusion of midazolam. The level of sedation of midazolam was evaluated applying OAA/S score and bispectral index（BIS） .The correlation between target- controlled blood concentration（Cp） and BIS was determined.The Cp, BIS, MAP, HR and SpO2 at different OAA/S were observed.RESULTS： When OAA/S score was 3, the required target-controlled blood concentration of midazolam was （122.8 ± 20.8） ng·mL^-1 in midazolam sedation patients.There was a good correction between BIS and Cp, and BIS =- 3.28Cp± 355.22（ r =-0.862 5, P 〈 0.01）.CONCLUSION：Target- controlled infusion of midazolam on conscious sedation for patients undergoing combined spinal - epldural anesthesia were satisfactory in controllability and level of sedation, and which did no impact on hemodynamics and respiratory function of patients.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第29期2284-2285,共2页
China Pharmacy
基金
河北省科研攻关项目(062761599)
关键词
腰-硬联合麻醉
咪达唑仑
清醒镇静
双频指数
Combined spinal - epidural anesthesia
Midazolam
Conscious sedation
Bispectral index
